ArticleJournal of oral microbiology2026
Microbiome and metabolome integrated analysis reveals oral microbiota alterations and associated metabolic pathways in allergic rhinitis.
Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Allergic rhinitis is a globally prevalent condition characterized by an increase in incidence. This study aimed to characterize differences in supragingival plaque microbial composition between patients with allergic rhinitis and healthy controls, and to explore the differential metabolites and enriched metabolic pathways to provide reference data for subsequent in-depth investigations into the pathogenesis and potential therapeutic targets of allergic rhinitis. Material and methods: We employed 16S rRNA gene high-throughput sequencing technology and untargeted metabolomics to analyze the supragingival plaque microbiota of 35 healthy individuals and 35 patients with allergic rhinitis. Results: At the genus level, Conclusion: Under the current inclusion criteria, this study identified significant alterations in the microbial composition of supragingival plaques in patients with allergic rhinitis. Additionally, using the current sample size, this study preliminarily characterised differential metabolites and pathways, providing initial clues for identifying therapeutic targets in allergic rhinitis.
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