Evidence map›Paper›PMID 42428793›Full record

ArticleNPJ dementia2026

An integrated lifestyle-, genetic- and metabolomics-based prediction model for mild cognitive aging in the HCHS/SOL.

Annah B Wyss, Yana Hrytsenko, Linfeng Hu, Iris J Broce, Robert C Kaplan, Wassim Tarraf, Bing Yu, Eric Boerwinkle, Qibin Qi, Myriam Fornage and 3 more

Abstract read
In one paragraph

Article in NPJ dementia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Annah B Wyss *CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA USA.
Yana Hrytsenko *CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA USA.
Linfeng Hu *CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA USA.
Iris J BroceDepartment of Neurosciences, University of California San Diego, La Jolla, CA USA.
Robert C KaplanDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY USA.
Wassim TarrafInstitute of Gerontology & Department of Healthcare Sciences, Wayne State University, Detroit, MI USA.
Bing YuDepartment of Epidemiology, School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX USA.
Eric BoerwinkleDepartment of Epidemiology, School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX USA.
Qibin QiDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY USA.
Myriam FornageDepartment of Epidemiology, School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX USA.
Charles DeCarliDepartment of Neurology, University of California Davis, Davis, CA USA.
Hector M GonzálezDepartment of Neurosciences, University of California San Diego, La Jolla, CA USA.
Tamar SoferCardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA USA.

Funding

SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Julie Secombe · 2021 to 2026
$7.0M
Using polygenic risk scores and omics to study how suboptimal sleep accelerates cognitive aging in diverse populationsR01AG080598 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Tamar Sofer · 2023 to 2026
$3.6M
Leveraging omics data to understand sleep health and its consequences among diverse Hispanics/LatinosR01HL161012 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Tamar Sofer · 2022 to 2026
$3.2M
Novel imaging genetic biomarkers for sporadic frontotemporal dementia through machine learningK01AG070376 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROCE-DIAZ, IRIS J · 2021 to 2025
$528k
NHLBI NIH HHS R01 HL161012NIA NIH HHS K01 AG070376NIA NIH HHS R01 AG080598NICHD NIH HHS P50 HD105352
6 · The paper itself

Abstract

Prediction models for cognitive aging measures have largely evaluated demographic variables and

Indexed as

BiomarkersComputational biology and bioinformaticsDiseasesRisk factors

Identifiers

PMID42428793
PMCPMC13345926

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.