ArticleCell reports. Physical science2026
Active regulation of intrinsic curvature by eukaryotic phospholipid metabolism.
Article in Cell reports. Physical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Ether linkages in phospholipids provide modular control of membrane mechanics.bioRxiv : the preprint server for biology · 2026Article
- Energetics of stalk intermediates elucidated from hydrostatic pressure effects on membrane fusion.bioRxiv : the preprint server for biology · 2026Article
- Saturated cardiolipins are potent disruptors of inner mitochondrial membrane structure and function.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
- Update of
Authors and funding
7 authors.
Funding
Abstract
Membranes contain thousands of different lipids, but it is poorly understood why their compositions vary across cell types and environments. We report that lipid metabolism balances the molecular curvature of phospholipids, a parameter that describes their shape and propensity to destabilize flat sheets. We utilized extreme hydrostatic pressures-similar to those found in the deep ocean-to change the shape (reduce the curvature) of phospholipids in growing cells. Yeast and human cells respond to this stress by increasing synthesis of distinct high-curvature lipid species. The results support a model in which eukaryotic cells actively regulate lipid composition to maintain their membranes in a frustrated state, a dynamic that could be important for maintaining core functions in membrane trafficking.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.