One-Step Synthesis of Cytocompatible Brushite-Mineralized Gellan Gum/Alginate Microgels via a Temperature-Controlled Approach.

Stanisław Marecik, Anna Kusibab, Krzysztof Pietryga, Elżbieta Pamuła

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Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Stanisław MarecikAGH University of Krakow, Faculty of Materials Science and Ceramics, Department of Biomaterials and Composites, al. A. Mickiewicza 30, Kraków 30-059, Poland.

Anna KusibabAGH University of Krakow, Faculty of Materials Science and Ceramics, Department of Biomaterials and Composites, al. A. Mickiewicza 30, Kraków 30-059, Poland.

Krzysztof PietrygaSilesian Park of Medical Technology Kardio-Med Silesia, Marii Curie-Skłodowskiej 10C, Zabrze 41-800, Poland.

Elżbieta PamułaAGH University of Krakow, Faculty of Materials Science and Ceramics, Department of Biomaterials and Composites, al. A. Mickiewicza 30, Kraków 30-059, Poland.ORCID https://orcid.org/0000-0002-0464-6189

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Injectable bioactive microgels (MGs) are in high demand in minimally invasive bone regeneration, but their fabrication presents significant challenges. Specifically, creating composite MGs that are structurally stablerequiring high polymer concentrationsand containing a bioactive mineral phase is technologically difficult due to high viscosity, leading to inconsistent particle formation and system clogging. Our objective was to develop a novel temperature-controlled emulsification method to overcome these limitations and to produce and characterize MG from a brushite-mineralized highly concentrated gellan gum/sodium alginate (GG/SA). The setup allowed us to successfully produce uniform spherical MG with a controllable mineral content of up to 30% and a mean diameter below 100 μm. SEM/EDS, FTIR, XRD, and TG analyses confirmed the successful incorporation of a nanocrystalline brushite phase, which provided significant structural stability to MGs.

Identifiers

PMID42428871

DOI10.1021/acsomega.5c12166

PMCPMC13347343

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LicenceCC BY

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