Photochemical Cascade Nitrile Activation via a Carbene-Nitrene Relay.

Bingyang Han, Zihui Gong, Guanwang Huang, Yajie Xing, Jiean Chen, Zhaofeng Wang

Abstract read

In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Bingyang HanState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P. R. China.

Zihui GongState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P. R. China.

Guanwang HuangState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P. R. China.

Yajie XingDepartment of Chemistry, The Hong Kong University of Science and Technology, Hong Kong, P. R. China.

Jiean ChenHigh-throughput Screening Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, P. R. China.ORCID https://orcid.org/0000-0003-0703-5831

Zhaofeng WangState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P. R. China.ORCID https://orcid.org/0000-0002-0547-8172

Funding

Guangdong Basic and Applied Basic Research Foundation 2025B1515020070National Natural Science Foundation of China 22571203Natural Science Foundation of Hunan Province 2025JJ50069

6 · The paper itself

Abstract

The deliberate integration of reactive intermediates into programmed bond-forming sequences represents a powerful approach for advancing organic synthesis and enabling novel transformations. Among these intermediates, transient nitrene species are particularly attractive due to their capacity to generate two new X─N covalent bonds. However, the development of nitrene-mediated reactions has been hindered by difficulties in controlling their high reactivity and the limited availability of efficient precursors. We hypothesized that a catalytic strategy enabling the sequential generation of carbene and nitrene intermediates could facilitate the cascade activation of common nitriles, thereby unveiling their latent potential as nitrene sources. In this work, we report a methodology for the catalytic generation of a sulfoxonium (S

Indexed as

carbenescascade reactionsnitrenesnitrile activationphotochemistry

Identifiers

PMID42429039

DOI10.1002/anie.9090329

PMCPMC13502624

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.