ArticleInternational journal of molecular medicine2026
Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging.
Article in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ovarian aging is a key cause of reproductive decline in women. Chronic inflammation and granulosa cell (GC) senescence are implicated in this process; however, the underlying cell‑type‑specific changes and regulatory mechanisms remain incompletely understood. The present study thus aimed to provide insight into these mechanisms. For this purpose, publicly available single‑cell transcriptomic data from human ovarian tissues in the Gene Expression Omnibus database (GSE202601) were analyzed, including four young donors (23‑29 years of age) and four aged donors (49‑54 years of age). Following quality control and integration, clustering, CellChat, pseudotime and SCENIC analyses were performed to define age‑related changes in cellular composition, intercellular communication and transcriptional regulation. Key findings were further supported by complementary
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