ArticleJournal of separation science2026
Quantitative Profiling and Metabolic Study of Caffeoylquinic Acids and Their Metabolites by Liquid Chromatography-Tandem Mass Spectrometry in Rats and Laying Hens.
Article in Journal of separation science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Quantitative Profiling and Metabolic Study of Caffeoylquinic Acids and Their Metabolites by Liquid Chromatography-Tandem Mass Spectrometry in Rats and Laying Hens.Journal of separation science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Caffeoylquinic acids are natural polyphenolic compounds with notable antioxidant and anti-inflammatory activities. This study developed and validated a sensitive high-performance liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of isochlorogenic acid A (ICQA) and 22 metabolites in serum. The method exhibited excellent sensitivity with limits of quantification of 0.625-1.25 µg/L (signal-to-noise ratio = 10), inter/intra-day precision below 15%, and comprehensive coverage of phase I/II and microbial metabolites. Application of the method in rats and laying hens demonstrated its robustness for pharmacokinetic profiling and cross-species validation, revealing a triphasic metabolic pattern of ICQA, the consistent metabolic endpoints of the accumulation of microbial metabolites, and a critical role of gut microbiota in ICQA metabolism. The developed platform provides a reliable analytical tool for comprehensive metabolism studies of phenolic compounds, with high throughput and reproducibility.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.