Evidence map›Paper›PMID 42429403›Full record

ArticlemSphere2026

mSphere of Influence: Damage in RNA virus infection-a feature or a bug?

Katherine C Barnett

Abstract read
In one paragraph

Article in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Katherine C BarnettDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0001-9552-5325

Funding

Regulation of Pathologic Inflammasome Responses to SARS-CoV-2R00AI175479 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Katherine Camille Barnett · 2025 to 2026
$493k
NIAID NIH HHS R00 AI175479
6 · The paper itself

Abstract

Katherine C. Barnett studies cell death and damage in viral infections, focusing on how these processes activate innate immunity and shape viral pathogenesis. In this mSphere of Influence article, she highlights how the work of Aguirre et al. (Nat Microbiol 2:17037, 2017, https://doi.org/10.1038/nmicrobiol.2017.37) changed her perception of how RNA viruses interact with pattern recognition receptors and how later the work of Wang et al. (Nature 616:152-158, 2023, https://doi.org/10.1038/s41586-023-05851-w) shaped her concept of cell death in viral infections. Framing these findings in different models of pathogen detection by the innate immune system, she reflects on how her understanding of the role of damage in RNA virus infection has evolved throughout her career.

Indexed as

Host-Pathogen InteractionsRNA VirusesRNA Virus InfectionsAnimalsCell DeathHumansImmunity, InnateInnate Immunity RecognitionReceptors, Pattern RecognitionReceptors, Pattern Recognitioncell deathdamage-associated molecular patternshost-pathogen interactionsinnate immunitypattern recognition receptorsRNA virus

Identifiers

PMID42429403
PMCPMC13410963

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.