Evidence map›Paper›PMID 42429561›Full record

ReviewJournal of bacteriology2026

Roles of divalent metals in the regulation of cyclic di-GMP signaling in bacteria.

Aathmaja Anandhi Rangarajan, Christopher M Waters

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of bacteriology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Aathmaja Anandhi RangarajanDepartment of Microbiology, Genetics and Immunology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0003-3471-0257
Christopher M WatersDepartment of Microbiology, Genetics and Immunology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0003-2336-7836

Funding

Exploring cyclic di-nucleotide signaling across the tree of life (Supplement)R35GM139537 · NIGMS · MICHIGAN STATE UNIVERSITY · PI WATERS, CHRISTOPHER M · 2021 to 2025
$2.9M
The contribution of novel cytidine deaminase regulatory systems to bacterial evolutionR01AI158433 · NIAID · MICHIGAN STATE UNIVERSITY · PI NEIDITCH, MATTHEW B, WATERS, CHRISTOPHER M · 2021 to 2025
$2.9M
NIAID NIH HHS R01 AI158433NIGMS NIH HHS R35 GM139537NIH HHS AI158433NIH HHS GM139537
6 · The paper itself

Abstract

Metals are essential co-factors that are important for the activity of many enzymes and, hence, bacterial life itself. Cyclic di-GMP (c-di-GMP) is an important signaling molecule that is prevalent across various bacterial phyla and involved in myriad physiological processes. The structure and function of diguanylate cyclase (DGCs) and phosphodiesterase (PDEs) domains that make and degrade c-di-GMP are also highly conserved. These enzymes are influenced by several signaling cues, such as temperature, oxygen, and small molecules, which determine the intracellular c-di-GMP levels and subsequent bacterial physiology. In this review, we summarize the current knowledge of the roles of divalent metals Mn

Indexed as

BacteriaCations, DivalentCyclic GMPMetalsSignal TransductionEscherichia coli ProteinsGene Expression Regulation, BacterialIronPhosphoric Diester HydrolasesPhosphorus-Oxygen Lyasesbis(3',5')-cyclic diguanylic acidCations, DivalentCyclic GMPdiguanylate cyclaseEscherichia coli ProteinsIronMetalsPhosphoric Diester HydrolasesPhosphorus-Oxygen Lyasescalciumcyclic di-GMPironmagnesiummanganesemetalzinc

Identifiers

PMID42429561
PMCPMC13492106

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.