Evidence map›Paper›PMID 42429614›Full record

ArticlemSystems2026

Higher abundance of

Hassan Diab, Robert F J Kullberg, Li-Fang Yeo, Irina Wikki, Veikko Salomaa, Aki Havulinna, Leo Lahti, Katariina Pärnänen, Sirpa Jalkanen, Marko Salmi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hassan DiabDivision of Medicine, Turku University Hospital, Turku, Finland.ORCID 0009-0004-8294-6576
Robert F J KullbergCenter for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0001-8269-9887
Li-Fang YeoDivision of Medicine, Turku University Hospital, Turku, Finland.ORCID 0000-0001-9275-0973
Irina WikkiDivision of Medicine, Turku University Hospital, Turku, Finland.
Veikko SalomaaDepartment of Internal Medicine, University of Turku, Turku, Finland.
Aki HavulinnaInstitute for Molecular Medicine Finland, FIMM-HiLIFE, Helsinki, Finland.
Leo LahtiDepartment of Computing, University of Turku, Turku, Finland.ORCID 0000-0001-5537-637X
Katariina PärnänenDepartment of Computing, University of Turku, Turku, Finland.
Sirpa JalkanenMediCity Research Laboratory, University of Turku, Turku, Finland.
Marko SalmiMediCity Research Laboratory, University of Turku, Turku, Finland.
Max NieuwdorpDepartment of Internal Medicine, Division of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Rob KnightDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-0975-9019
W Joost WiersingaCenter for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Joonatan PalmuDivision of Medicine, Turku University Hospital, Turku, Finland.
Teemu NiiranenDivision of Medicine, Turku University Hospital, Turku, Finland.

Funding

Academy Research Fellow Funding 368511European Union's Horizon Europe Framework programme for research and innovation 2021-2027 under the Marie Sklodowska-Curie grant agreement No 101126611Finnish Research CouncilJuho Vainion Säätiö (Reppy Institute)Paavo Nurmen Säätiö (Paavo Nurmi Foundation)Research Council of Finland (AKA)Research Council of Finland (AKA) 348439Sigrid Juséliuksen Säätiö (Sigrid Jusélius Stiftelse)Suomen Lääketieteen Säätiö (Finnish Medical Foundation)Sydäntutkimussäätiö (Finnish Foundation for Cardiovascular Research)The ImmuDocs Doctoral Education PilotThe Wellbeing Services County of Southwest Finland
6 · The paper itself

Abstract

The human gut microbiome has been suggested to be linked with the risk of developing sepsis, a life-threatening medical emergency. However, it remains unclear whether the gut microbiome is an independent predictor of long-term sepsis risk in the general adult population. Here, we investigated for the first time the prospective association between the gut microbiome and incident sepsis in the general population. The study sample (FINRISK) consisted of 6,372 individuals who underwent fecal sampling in 2002 and were followed for incident sepsis. We used multivariable-adjusted models to study the associations of microbial alpha-diversity, beta-diversity, taxa, butyrate producers, and predicted pathways with incident sepsis. Two hundred and forty participants developed sepsis over a follow-up of 19.8 years. A 1-SD increase in

Indexed as

Faecalibacterium prausnitziiGastrointestinal MicrobiomeSepsisAdultAgedFecesFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesRisk FactorsFaecalibacterium prausnitziigut microbiomeprospective studysepsis

Identifiers

PMID42429614
PMCPMC13483378

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.