Evidence map›Paper›PMID 42429620›Full record

ArticlemBio2026

A β-carboline natural product induces oxidative stress in

Bradley Laflamme, Christopher Blackman, Lauren Ryder, Mackenzie E W Loranger, Weibin Ma, Yunjin Lee, Margaret Balcerzak, Jessie MacAlpine, Luke Whitesell, Nicholas J Talbot and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bradley LaflammeDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-8220-8128
Christopher BlackmanAgriculture and Agri-Food Canada, Ottawa, Ontario, Canada.
Lauren RyderThe Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
Mackenzie E W LorangerDepartment of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Weibin MaThe Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
Yunjin LeeDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Margaret BalcerzakAgriculture and Agri-Food Canada, Ottawa, Ontario, Canada.
Jessie MacAlpineFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Luke WhitesellDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Nicholas J TalbotThe Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
Keiko YoshiokaDepartment of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Rajagopal SubramaniamAgriculture and Agri-Food Canada, Ottawa, Ontario, Canada.
Nicole RobbinsDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-2821-9269
Leah E CowenDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-5797-0110

Funding

CIHR FDN-154288Natural Sciences and Engineering Research Council of Canada RGPIN-2026-05365
6 · The paper itself

Abstract

The emergence of fungicide-resistant pathogens of many agronomically important crop species necessitates the development of novel strategies for controlling diseases caused by fungi. β-carbolines encompass a wealth of natural products with diverse modes of action that lead to a myriad of phenotypic effects. While these molecules have been previously described as having antifungal activity against select species, the potential of β-carbolines to limit agricultural diseases caused by fungi has not been fully explored. Here, we report that several β-carbolines strongly inhibit growth and conidial germination in the devastating cereal pathogen

Indexed as

Antifungal AgentsBiological ProductsCarbolinesFungicides, IndustrialFusariumOxidative StressPlant DiseasesBotrytisMembrane Potential, MitochondrialReactive Oxygen SpeciesSpores, FungalVirulenceAntifungal AgentsBiological ProductsCarbolinesFungicides, IndustrialReactive Oxygen Speciesantifungal agentsfungicideFusarium graminearumphytopathogensreactive oxygen speciesstrobilurinsβ-carbolines

Identifiers

PMID42429620
PMCPMC13463887

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.