Evidence map›Paper›PMID 42429850›Full record

ReviewFolia microbiologica2026

From symptom management to immune prevention: a comprehensive review of chikungunya treatment and vaccine development.

Xin Li, Zijun Yuan, Junjie Ni, Dinglei Rao, Wenxian Yin, Xu Wu, Mingxing Li, Fukuan Du, Yueshui Zhao, Jing Shen and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Folia microbiologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xin Li *Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.
Zijun Yuan *Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.
Junjie Ni *Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.
Dinglei RaoLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.
Wenxian YinDepartment of Pharmacy, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, 646000, China.
Xu WuLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.
Mingxing LiLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.
Fukuan DuLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.
Yueshui ZhaoLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.
Jing ShenLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.
Xi HeInfectious Disease Department, The Six School of Clinical Medicine, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, No.35, Yinquan North Road, Qingcheng District, Qingyuan, Guangdong, 511518, China.
Chi Hin ChoLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China. chcho@cuhk.edu.hk.
Zhangang XiaoLaboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China. zhangangxiao@swmu.edu.cn.ORCID http://orcid.org/0000-0003-4265-5833

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chikungunya is an acute illness caused by the chikungunya virus (CHIKV) and spread by Aedes mosquitoes. It has now been reported in over 100 countries, posing an increasing public health challenge. The disease presents with a range of symptoms, most commonly fever, rash, and joint pain. There are still no specific antiviral drugs available, and treatment remains largely supportive. Vaccine development has made some headway, but challenges around safety, immune response, and real-world use persist. This article reviews what is known about the epidemiology, pathogenesis, clinical features, treatment options, and vaccine progress for chikungunya. It also looks at the key bottlenecks that continue to hinder translation from basic research to clinical practice, and argues that new technology platforms and stronger international collaboration are needed to advance the development of targeted drugs and safe, effective vaccines-so that we can better tackle this global health threat.

Indexed as

Chikungunya virusEpidemiologyPathogenesisTreatmentVaccine

Identifiers

PMID42429850

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.