Evidence map›Paper›PMID 42429880›Full record

ArticleEndocrine2026

Pasireotide induces proteins related to autophagy in cancer cells.

Madan Sigdel, Saikat Fakir, Md Matiur Rahman Sarker, Nektarios Barabutis

Abstract read
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In one paragraph

Article in Endocrine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Madan Sigdel *School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA, 71201, USA.
Saikat FakirSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA, 71201, USA.
Md Matiur Rahman SarkerSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA, 71201, USA.
Nektarios Barabutis *School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA, 71201, USA. barabutis@ulm.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the possibility that Pasireotide (PAS), which is a synthetic somatostatin analog (SSA), induces proteins related to autophagy in cancer cells.

methodsMDA-MB-468 and HeLa human cancer cells were exposed to PAS or vehicle for 8, 24 and 32 h, to assess possible effects in autophagy-related proteins. Western blot analysis was utilized to assess changes in protein expression levels due to PAS exposure.

resultsPAS treatment induces the expression of the autophagy-related protein (ATG)-3, ATG-7, and Beclin-1 in MDA-MB-468 and HeLa cells.

conclusionsOur findings suggest that the beneficial effects of PAS in cancers may involve autophagy. Further studies will attempt to elucidate the underlying mechanisms mediating those effects.

Indexed as

AutophagySomatostatinAutophagy-Related Protein 7Beclin-1Cell Line, TumorHeLa CellsHumansAutophagy-Related Protein 7Beclin-1BECN1 protein, humanpasireotideSomatostatinNeuroendocrine tumorsOncologySomatostatinSynthetic somatostatin analogs

Identifiers

PMID42429880

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.