ArticleFunctional & integrative genomics2026
Rs1347093 polymorphism contributes to radiation pneumonitis in lung cancer patients through regulating miR-216a-5p expression.
Article in Functional & integrative genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathogenesis of radiation pneumonitis (RP) is complex, involving multiple genetic and molecular factors. Single-nucleotide polymorphisms (SNPs) at specific microRNA gene loci can influence miRNA expression, even affect disease progression. Genotype distribution of rs1347093 in RP and non-RP groups was analyzed, and the underlying mechanism was explored in human pulmonary microvascular endothelial cells (HPMECs). TaqMan SNP genotyping assay was used to complete the genotyping in 545 subjects with lung cancer, of whom 260 had RP and 285 did not. HPMECs were exposed to 15 Gy of X-rays to mimic RP in vitro. mRNA levels were measured via RT-qPCR, while cell apoptosis was assessed via flow cytometry assay. Targeting relationship between the miRNA and the gene was ensured via dual luciferase reporter and RIP assay. The composition ratio of rs1347093 CA genotype carriers in RP group exhibited a significant increase in relation to the non-RP group. The risk of developing pneumonia was 1.827 times higher among CA carriers than CC genotype carriers. Rs1347093 CA/AA genotype remained significantly positively associated with RP risk after controlling for confounding factors. The expression of miR-216a-5p in RP patients exhibited genotype-specific expression patterns, with a significant decrease detected in CA/AA genotype carriers. In HPMECs, miR-216a-5p overexpression attenuated X-ray-mediated apoptosis and ICAM-1 release by targeting and sequestering TGFβR2. Rs1347093 may be a potential genetic marker for susceptibility to RP. It may affect the inflammatory imbalance in RP patients by regulating miR-216a-5p expression.
Indexed as
Identifiers
42430022What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.