ReviewSleep & breathing = Schlaf & Atmung2026
Sleep-disordered breathing as a risk factor for sarcopenia in the elderly: a narrative review.
Review in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionObstructive sleep apnea (OSA) and sarcopenia are highly prevalent in aging adults, both contributing to morbidity and diminished quality of life. Despite plausible biological connections through sleep fragmentation, hormonal dysregulation, and chronic inflammation, their clinical relationship remains poorly understood.
methodsThis narrative review synthesizes current evidence on pathophysiological links between these conditions.
resultsPopulation studies consistently demonstrate increased sarcopenia risk in patients with OSA, with NHANES data showing 12% versus 5.5% prevalence. Recent Mendelian randomization studies provide genetic instrumental variable evidence supporting bidirectional causal relationships. Key mechanisms include sleep fragmentation disrupting growth hormone release, chronic inflammation promoting muscle catabolism, and respiratory muscle dysfunction creating vicious cycles. Population variability, comorbidities such as chronic obstructive pulmonary disease (COPD), and lifestyle factors including smoking further shape this relationship. Limited evidence suggests CPAP therapy may partially reverse these effects.
conclusionClinical practice should consider routine sarcopenia screening in patients with OSA and sleep assessment in sarcopenic individuals.
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Registered trials
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