Evidence map›Paper›PMID 42430095›Full record

ArticleInternational urology and nephrology2026

Single-cell analysis reveals the molecular regulatory mechanisms of high mobility group box 1 in prostate cancer development and progression.

Haojie Mo, Haoyang Zhang, Peng Li, Zhijun Miao, Gang Shen, Jiale Sun

Abstract read
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In one paragraph

Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haojie MoDepartment of Urology, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, No. 9, Chongwen Road, Suzhou Industrial Park, Suzhou, 215123, Jiangsu, China.
Haoyang ZhangDepartment of Urology, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, No. 9, Chongwen Road, Suzhou Industrial Park, Suzhou, 215123, Jiangsu, China.
Peng LiDepartment of Urology, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, No. 9, Chongwen Road, Suzhou Industrial Park, Suzhou, 215123, Jiangsu, China.
Zhijun MiaoDepartment of Urology, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, No. 9, Chongwen Road, Suzhou Industrial Park, Suzhou, 215123, Jiangsu, China.
Gang ShenDepartment of Urology, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, No. 9, Chongwen Road, Suzhou Industrial Park, Suzhou, 215123, Jiangsu, China. gshen119@163.com.
Jiale SunDepartment of Urology, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, No. 9, Chongwen Road, Suzhou Industrial Park, Suzhou, 215123, Jiangsu, China. sunjiale93@163.com.

Funding

Suzhou Industrial Park Clinical Medical Expert Team Introduction Project 0202140004Suzhou Industrial Park Healthcare Talent Support Initiative 202412
6 · The paper itself

Abstract

High mobility group box 1 (HMGB1), which plays a crucial role in cancer progression, remains incompletely elucidated due to the high heterogeneity and complex tumor microenvironment of prostate cancer (PCa). This study, through single-cell transcriptomic analysis, provided a comprehensive elucidation of cellular heterogeneity in PCa tissues and revealed the essential role of HMGB1 in the progression of PCa by using in vitro cell experiments. Single-cell analysis revealed that an epithelial subpopulation with high levels of HMGB1 (HMGB1+ Malignant LE) significantly increased in PCa tissues, which was closely correlated with the malignant characteristics of the tumor. KEGG enrichment analysis revealed that pathways associated with autophagy, mitophagy, and apoptosis were significantly enriched in the HMGB1+ Malignant LE sub-group. In vitro cell experiments further confirmed that knocking down HMGB1 significantly inhibited the proliferation, migration, and invasive capacity of PCa cells, while inducing cellular apoptosis and cell cycle arrest. These findings suggest that HMGB1 promotes PCa malignancy by modulating tumor cell metabolism and cellular cycle progression. This study provides novel insights into the role of HMGB1 in PCa and lays theoretical groundwork for the development of therapeutic strategies targeting HMGB1.

Indexed as

HMGB1Molecular regulationProstate cancerSingle-cell transcriptomicsTumor progression

Identifiers

PMID42430095

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.