ArticleInfection2026
Syphilis and neurosyphilis in people living with HIV: analysis of cerebrospinal fluid findings.
Article in Infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSyphilis and neurosyphilis remain significant comorbidities among people living with human immunodeficiency virus (HIV). Data on cerebrospinal fluid (CSF) findings in co-infected individuals are limited. This study aimed to determine which CSF parameters and HIV-related immunologic and virologic markers are associated with neurosyphilis in people living with HIV (PLWH), and to assess the impact of antiretroviral therapy (ART) on these relationships.
methodsWe conducted a retrospective analysis of 211 people living with HIV undergoing syphilis serology and CSF testing at a tertiary care center between 2011 and 2017. Patients were stratified by syphilis stage and ART status. CSF parameters, CD4
resultsNeurosyphilis was diagnosed in 10% (n = 21) of the study population. Treponema pallidum particle agglutination (TPPA) titers ≥ 1024 in CSF were significantly associated with neurosyphilis (p = 0.001). No significant association was observed between neurosyphilis and CD4
conclusionsHigh CSF TPPA titers, particularly ≥ 1024, are strong indicators of neurosyphilis among PLWH. CD4
Indexed as
Identifiers
42430111What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.