Evidence map›Paper›PMID 42430481›Full record

ArticleScience advances2026

Barium senses subtle pore changes in a voltage-gated K

Lei Huang, Nitzan Daus, Yuyin Wang, Guohui Zhang, Manar Khier, Ariel Ben-Bassat, Jingyi Shi, Lu Zhao, Borui Zhang, Lu Han and 3 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lei HuangDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Diseases, Washington University in St. Louis, MO 63130, USA.ORCID 0009-0008-1728-3509
Nitzan DausDepartment of Physiology and Pharmacology, Gray Faculty of Medical and Health Sciences and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 6997801, Israel.ORCID 0009-0005-0600-5878
Yuyin WangDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Diseases, Washington University in St. Louis, MO 63130, USA.
Guohui ZhangDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Diseases, Washington University in St. Louis, MO 63130, USA.ORCID 0000-0001-6905-0637
Manar KhierDepartment of Physiology and Pharmacology, Gray Faculty of Medical and Health Sciences and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 6997801, Israel.ORCID 0009-0005-3556-4986
Ariel Ben-BassatDepartment of Physiology and Pharmacology, Gray Faculty of Medical and Health Sciences and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 6997801, Israel.ORCID 0000-0002-7403-2633
Jingyi ShiDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Diseases, Washington University in St. Louis, MO 63130, USA.ORCID 0009-0003-6252-7262
Lu ZhaoDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Diseases, Washington University in St. Louis, MO 63130, USA.ORCID 0000-0003-3533-7693
Borui ZhangDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Diseases, Washington University in St. Louis, MO 63130, USA.
Lu HanDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Diseases, Washington University in St. Louis, MO 63130, USA.ORCID 0009-0009-8938-7726
Yoni HaitinDepartment of Physiology and Pharmacology, Gray Faculty of Medical and Health Sciences and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 6997801, Israel.ORCID 0000-0002-1648-6792
Bernard AttaliDepartment of Physiology and Pharmacology, Gray Faculty of Medical and Health Sciences and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 6997801, Israel.ORCID 0000-0003-1066-7047
Jianmin CuiDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Diseases, Washington University in St. Louis, MO 63130, USA.ORCID 0000-0002-9198-6332

Funding

A full spectrum rational approach to identify antiarrhythmic agents targeting IKs ChannelsR01HL166628 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI Jianmin Cui, RICHARD Z LIN · 2023 to 2026
$2.8M
Gating Mechanisms of KCNQ1/IKS ChannelsR01HL155398 · NHLBI · WASHINGTON UNIVERSITY · PI CUI, JIANMIN · 2021 to 2024
$2.5M
NHLBI NIH HHS R01 HL155398NHLBI NIH HHS R01 HL166628
6 · The paper itself

Abstract

In classic models of voltage-dependent channel activation, the pore only opens after the voltage sensor domains (VSDs) activate in an "all-or-none" fashion. Whether the VSD alters open pore properties remains unclear. Here, we examine the properties of the KCNQ1 channel pore in relation with the VSD and regulatory subunits that are located outside of the pore using barium ion (Ba

Indexed as

BariumIon Channel GatingKCNQ1 Potassium ChannelPotassium Channels, Voltage-GatedAnimalsHumansProtein SubunitsBariumKCNQ1 Potassium ChannelPotassium Channels, Voltage-GatedProtein Subunits

Identifiers

PMID42430481
PMCPMC13353409

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.