ArticleScience advances2026
Progressive intestinal tumor cell plasticity, Myc activation, and loss of Lgr5
Marika Lassila, Fatemeh Seyednasrollah, Cinzia Bessone, Maritta Räisänen, Inkeri Vuori, Davide G Berta, Johanna Aspholm, Tatiana V Petrova, Lauri A Aaltonen, Kari Alitalo and 1 more
Abstract read
In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Marika LassilaTranslational Cancer Medicine Program, Research Programs Unit, University of Helsinki, Helsinki 00014, Finland.ORCID 0009-0004-9591-2156 Fatemeh SeyednasrollahTranslational Cancer Medicine Program, Research Programs Unit, University of Helsinki, Helsinki 00014, Finland.ORCID 0009-0004-7248-1218 Cinzia BessoneTranslational Cancer Medicine Program, Research Programs Unit, University of Helsinki, Helsinki 00014, Finland.
Maritta RäisänenMedicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki 00014, Finland.ORCID 0000-0002-2764-0433 Inkeri VuoriTranslational Cancer Medicine Program, Research Programs Unit, University of Helsinki, Helsinki 00014, Finland.
Davide G BertaMedicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki 00014, Finland.ORCID 0000-0002-0847-998X Johanna AspholmTranslational Cancer Medicine Program, Research Programs Unit, University of Helsinki, Helsinki 00014, Finland.ORCID 0009-0005-8999-2695 Tatiana V PetrovaDepartment of Fundamental Oncology, University of Lausanne, and Ludwig Institute for Cancer Research Lausanne, Lausanne, Switzerland.ORCID 0000-0002-0563-6521 Lauri A AaltonenMedicum/Department of Medical and Clinical Genetics, University of Helsinki, Helsinki 00014, Finland.ORCID 0000-0001-6839-4286 Kari AlitaloTranslational Cancer Medicine Program, Research Programs Unit, University of Helsinki, Helsinki 00014, Finland.ORCID 0000-0002-7331-0902 Pauliina KallioTranslational Cancer Medicine Program, Research Programs Unit, University of Helsinki, Helsinki 00014, Finland.ORCID 0000-0001-6374-6203 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Plasticity, the capability of tumor cells to go through phenotypic transitions, promotes colorectal cancer (CRC) progression and treatment resistance. Although plasticity is evident in advanced CRCs, little is known about plasticity in early-stage tumors and tumor stem cells. Here, we demonstrate that a plastic cell state (PCS) is present already in polyps from patients with familial adenomatous polyposis and in mouse intestinal adenomas, in which PCS is associated with
Indexed as
Cell PlasticityIntestinal NeoplasmsNeoplastic Stem CellsProto-Oncogene Proteins c-mycReceptors, G-Protein-CoupledWnt ProteinsAdenomatous Polyposis ColiAnimalsCell DifferentiationCell LineageCell ProliferationGene Expression Regulation, NeoplasticHomeodomain ProteinsHumansLymphoid Enhancer-Binding Factor 1MiceHomeodomain ProteinsLef1 protein, mouseLGR5 protein, humanLgr5 protein, mouseLymphoid Enhancer-Binding Factor 1Prospero-Related Homeobox 1 ProteinProto-Oncogene Proteins c-mycReceptors, G-Protein-CoupledTumor Suppressor ProteinsWnt Proteins
Identifiers
PMID42430492
PMCPMC13353423
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390