ReviewJACC. Basic to translational science2026
Biomechanical Determinants of Plaque Erosion: Translational Implications and Precision Care.
Review in JACC. Basic to translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plaque erosion is a major cause of acute coronary syndromes and is characterized by endothelial denudation, fibrous-cap integrity, and platelet-rich thrombosis. Advances in intracoronary optical coherence tomography have enabled in vivo identification of erosion, revealing unique clinical profiles and therapeutic opportunities, including selectively avoiding stents. Increasing evidence implicates local mechanical forces as central drivers of endothelial injury in erosion. Computational biomechanics, including fluid dynamics and emerging optical coherence tomography-based finite element analysis, allow detailed quantification of hemodynamic and structural stresses at plaque surfaces. These models provide mechanistic insights into how flow disturbance, plaque geometry, and wall stress may converge to trigger erosion. Integrating biomechanical signatures with erosion-associated biological pathways may refine risk stratification, guide conservative management, and identify new therapeutic targets. This review integrates fluid and emerging solid mechanics approaches with endothelial biology to provide a comprehensive mechanistic overview of plaque erosion and outlines priorities for translating biomechanics into precision care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.