Evidence map›Paper›PMID 42431855›Full record

ArticleNature communications2026

Resting-state electroretinography reveals pathological retinal oscillations in retinitis pigmentosa mice and patients.

David G Litvin, Alexia Boizot, Andrea Corna, Aurélie Navarro, Josiane Keller, Marc O Heuschkel, Adrien Roux, Günther Zeck, Hoai Viet Tran, Diego Ghezzi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David G LitvinOphthalmic and Neural Technologies Laboratory, Department of Ophthalmology, University of Lausanne, Hôpital ophtalmique Jules-Gonin, Fondation Asile des Aveugles, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-7688-5894
Alexia BoizotOphthalmic and Neural Technologies Laboratory, Department of Ophthalmology, University of Lausanne, Hôpital ophtalmique Jules-Gonin, Fondation Asile des Aveugles, Lausanne, Switzerland.
Andrea CornaBiomedical Electronics and Systems, Institute of Biomedical Electronics, Technische Universität Wien, Vienna, Austria.ORCID http://orcid.org/0000-0002-3209-6719
Aurélie NavarroCentre d'Investigation Clinique, Department of Ophthalmology, University of Lausanne, Hôpital ophtalmique Jules-Gonin, Fondation Asile des Aveugles, Lausanne, Switzerland.
Josiane KellerCentre d'Investigation Clinique, Department of Ophthalmology, University of Lausanne, Hôpital ophtalmique Jules-Gonin, Fondation Asile des Aveugles, Lausanne, Switzerland.
Marc O HeuschkelTissue Engineering Group, School of Engineering, Architecture and Landscape of Geneva (HEPIA), University of Applied Sciences and Arts Western Switzerland (HES-SO), Geneva, Switzerland.ORCID http://orcid.org/0000-0001-6463-0587
Adrien RouxTissue Engineering Group, School of Engineering, Architecture and Landscape of Geneva (HEPIA), University of Applied Sciences and Arts Western Switzerland (HES-SO), Geneva, Switzerland.ORCID http://orcid.org/0000-0001-7618-6129
Günther ZeckBiomedical Electronics and Systems, Institute of Biomedical Electronics, Technische Universität Wien, Vienna, Austria.ORCID http://orcid.org/0000-0003-3998-9883
Hoai Viet TranOculogenetics unit, Department of Ophthalmology, University of Lausanne, Hôpital ophtalmique Jules-Gonin, Fondation Asile des Aveugles, Lausanne, Switzerland.
Diego GhezziOphthalmic and Neural Technologies Laboratory, Department of Ophthalmology, University of Lausanne, Hôpital ophtalmique Jules-Gonin, Fondation Asile des Aveugles, Lausanne, Switzerland. info@ghezzilab.org.ORCID http://orcid.org/0000-0002-0554-7510

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinal remodeling occurs in both retinitis pigmentosa and age-related macular degeneration. However, it is still unknown whether spared retinal circuits are also functionally altered. Functional changes have been observed in animal models of retinitis pigmentosa, including the emergence of bursting oscillatory activity in retinal ganglion cells. Yet, comparable oscillatory activity, or other functional alterations, has not been demonstrated in patients. To address this gap, here we report a non-invasive corneal neurotechnology measuring in-vivo resting-state electroretinography and analyzing its frequency content and temporal characteristics to identify biomarkers of functional remodeling. We document that retinal remodeling induces bursting oscillatory activity in-vivo in retinitis pigmentosa mouse models and translate these results to patients. Moreover, we showed in mice that bursting oscillatory activity can be pharmacologically modulated in-vivo. Furthermore, reducing this oscillatory activity increases retinal excitability to electrical stimulation. These results are crucial for a better understanding of retinal degeneration and contribute to sight restoration efforts.

Indexed as

ElectroretinographyRetinaRetinitis PigmentosaAnimalsDisease Models, AnimalElectric StimulationFemaleHumansMaleMiceMice, Inbred C57BLRetinal Ganglion Cells

Identifiers

PMID42431855
PMCPMC13482292

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.