ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026
Psychedelics produce enduring enhancement of reward responsiveness in male rats.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
9 authors.
Funding
Abstract
Anhedonia, the blunted responsiveness to previously rewarding stimuli, is a core symptom of several psychiatric disorders. Ketamine and psilocybin have shown promising evidence in ameliorating anhedonic symptoms in clinical trials. The Probabilistic Reward Task (PRT) was developed to objectively quantify reward responsiveness in clinical populations and laboratory animals. Here, the PRT was used to explore acute and sustained effects of several psychedelics and relevant pharmacological comparators on reward responsiveness in rats (n = 12/group, n = 84/total). Reward responsiveness was significantly increased following administration of psilocybin (0.1-1 mg/kg) or ketamine (10 mg/kg) acutely, and the effect persisted 24 hours after dosing. The effects of psilocybin, but not ketamine, on reward responsiveness were blocked in a dose-dependent manner by pretreatment with the 5-HT
Identifiers
42432161What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.