ArticleApplied microbiology and biotechnology2026
Endophytic Aspergillus glaucus as a novel epothilone B producer: Antiproliferative activity and in silico analysis.
Article in Applied microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Epothilones are among the most potent anticancer agents, particularly against drug-resistant tumors, owing to their high affinity for β-tubulin stabilization, inhibiting the microtubule disassembly, ultimately leading to cell cycle arrest. However, their limited natural availability has restricted broader clinical and industrial exploitation. Accordingly, this study aimed to screen novel fungal isolates with sustainable and high metabolic capacity for epothilone production. Aspergillus glaucus OR342865.1, an endophyte isolated from the palm tree Latania lontaroides, exhibited the highest epothilone productivity (240 µg/L) upon response surface methodology optimization. The chemical identity of the purified compound was resolved by different chromatographic and spectroscopic analyses, revealing a structural profile consistence with authentic epothilone B. The putative epothilone B displayed potent cytotoxic activity against HepG-2, MCF-7, and HCT-116 cell lines, with half-maximal inhibitory concentration (IC
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