Evidence map›Paper›PMID 42432326›Full record

ArticleOncogene2026

ESRP1-regulated DNMT3B isoform switching determines the malignant potential of pancreatic cancer.

Eunji Hong, Hyeyeon Park, Junil Kim, Jin Muk Kang, Sujin Park, Taehong Min, Jinah Park, Kyoungwha Pang, Pyunggang Kim, Minjung Son and 13 more

Abstract read
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In one paragraph

Article in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Eunji Hong *GILO Institute, GILO Foundation, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-0695-1275
Hyeyeon Park *GILO Institute, GILO Foundation, Seoul, Republic of Korea.ORCID http://orcid.org/0009-0006-7951-9666
Junil KimSchool of Systems Biomedical Science, Soongsil University, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-1202-1808
Jin Muk KangDepartment of Pediatric Hematology & Oncology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Sujin ParkGILO Institute, GILO Foundation, Seoul, Republic of Korea.
Taehong MinSchool of Systems Biomedical Science, Soongsil University, Seoul, Republic of Korea.
Jinah ParkGILO Institute, GILO Foundation, Seoul, Republic of Korea.
Kyoungwha PangGILO Institute, GILO Foundation, Seoul, Republic of Korea.
Pyunggang KimGILO Institute, GILO Foundation, Seoul, Republic of Korea.
Minjung SonGILO Institute, GILO Foundation, Seoul, Republic of Korea.
Akira OoshimaGILO Institute, GILO Foundation, Seoul, Republic of Korea.
Daeun KimDepartment of Molecular Science and Technology, Ajou University, Suwon, South Korea.
Jeongeun ImDepartment of Molecular Science and Technology, Ajou University, Suwon, South Korea.
Wooil KwonDepartment of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Hideyuki TakeshimaHoshi University, Shinagawa-ku, Tokyo, Japan.
Ja-Lok KuDepartment of Biomedical Sciences/Department of Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-7090-537X
Hongbeom KimDepartment of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Toshikazu UshijimaHoshi University, Shinagawa-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0003-3405-7817
Jin-Young JangDepartment of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Yong Jung KwonGILO Institute, GILO Foundation, Seoul, Republic of Korea.
Daechan ParkDepartment of Molecular Science and Technology, Ajou University, Suwon, South Korea.
Seok Hee ParkDepartment of Biological Sciences, College of Natural Science, Sungkyunkwan University, Suwon, Republic of Korea.ORCID http://orcid.org/0000-0002-6210-4927
Seong-Jin KimGILO Institute, GILO Foundation, Seoul, Republic of Korea. jasonsjkim@gilo.or.kr.ORCID http://orcid.org/0000-0003-4335-8793

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial splicing regulatory protein 1 (ESRP1) is a key regulator of epithelial-mesenchymal transition (EMT) and cancer progression, including in pancreatic ductal adenocarcinoma (PDAC). We show that ESRP1-mediated isoform switching of DNA methyltransferase 3B (DNMT3B) correlates with the metastatic potential of pancreatic cancer cells. The expression of DNMT3B splicing variants was closely linked to ESRP1 level. Ectopic expression of mesenchymal DNMT3B isoforms 3 and 7, lacking part of the methyltransferase catalytic domain, significantly enhanced lung metastasis and tumor growth, while epithelial DNMT3B isoforms 1 and 2, with an intact catalytic domain, suppressed these effects in mouse models. Differential expression of DNMT3B isoforms also correlated with overall survival in PDAC patients. Deletion of exons 21-22, differentially spliced region between epithelial and mesenchymal isoforms, increased cell proliferation and migration, similar to mesenchymal DNMT3B. RNA sequencing revealed that mesenchymal DNMT3B isoforms 3 and 7 were associated with aggressive tumor phenotypes. Among differentially expressed target genes of DNMT3B isoforms, Fibulin 1 (FBLN1), a key regulator of the tumor microenvironment, regulates cancer cell migration and EMT. Taken together, our results highlight the central role of ESRP1-mediated DNMT3B isoform switching in pancreatic cancer progression and metastasis and suggest that DNMT3B isoforms may serve as potential biomarkers for this disease.

Indexed as

Carcinoma, Pancreatic DuctalDNA (Cytosine-5-)-MethyltransferasesPancreatic NeoplasmsRNA-Binding ProteinsAlternative SplicingAnimalsCell Line, TumorCell MovementCell ProliferationDNA Methyltransferase 3BEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansMiceProtein IsoformsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BESRP1 protein, humanProtein IsoformsRNA-Binding Proteins

Identifiers

PMID42432326

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.