Identification of VAYPQCV, a Gastrointestinally Stable Competitive DPP-IV Inhibitory Peptide from Bitter Leaf (Vernonia amygdalina).

Fitri Widya Handayani, Christoper Caesar Yudho Sutopo, Wei-Ting Hung, Isnawati, Aji Sutrisno, Jue-Liang Hsu

Abstract read

In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

6 authors.

Fitri Widya Handayani *Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung, 91201, Taiwan.

Christoper Caesar Yudho Sutopo *Department of Animal Science and Technology, National Taiwan University, Taipei City, 106037, Taiwan.

Wei-Ting HungInstitute of Food Science and Technology, National Taiwan University, Taipei, 106038, Taiwan.

IsnawatiAquaculture Program, Faculty of Food Security, Universitas Negeri Surabaya, Surabaya, 60286, Indonesia.

Aji SutrisnoDepartment of Food Science and Biotechnology, Faculty of Agroindustrial and Biosystems Technology, Brawijaya University, Malang, 65145, Indonesia. aji_sutrisno@ub.ac.id.

Jue-Liang HsuDepartment of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung, 91201, Taiwan. jlhsu@mail.npust.edu.tw.

Funding

National Science and Technology Council NSTC 114-2637-M-020-001

6 · The paper itself

Abstract

Among hydrolysates generated from bitter leaf (Vernonia amygdalina) proteins using multiple proteases, the thermolysin-derived hydrolysate exhibited the strongest inhibition toward human dipeptidyl peptidase IV (DPP-IV). Bioassay-guided RP-HPLC fractionation coupled with LC-MS/MS analysis yielded five candidate peptides for synthesis and validation, among which the heptapeptide VAYPQCV (VV7) showed the strongest inhibitory activity with an IC

Indexed as

Dipeptidyl Peptidase 4Dipeptidyl-Peptidase IV InhibitorsPeptidesAmino Acid SequenceBioactive Peptides, DietaryChromatography, High Pressure LiquidHumansKineticsMolecular Docking SimulationPlant LeavesPlant ProteinsTandem Mass SpectrometryBioactive Peptides, DietaryDipeptidyl Peptidase 4Dipeptidyl-Peptidase IV InhibitorsPeptidesPlant ProteinsCompetitive inhibitionDPP-IV inhibitory peptideSimulated gastrointestinal digestionType 2 diabetesVAYPQCVVernonia amygdalina

Identifiers

PMID42432351

DOI10.1079/BJN20041189

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.