ArticleJournal of the American Heart Association2026
Panvascular Changes Under Intensive Medical Therapy in Intracranial Atherosclerotic Steno-Occlusive Disease.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
backgroundWhile intensive medical therapy improves culprit plaque characteristics in intracranial atherosclerotic steno-occlusive disease, its broader effects on the intracranial arterial tree, venous pathways, and meningeal lymphatic system remain unclear. We explored longitudinal panvascular changes in patients with intracranial atherosclerotic steno-occlusive disease under intensive therapy.
methodsWe included patients with a first-ever intracranial atherosclerotic steno-occlusive disease-related stroke who received intensive medical therapy and underwent multimodal magnetic resonance imaging at baseline and 6-month follow-up. Quantitative assessments included plaque burden and lumen area at the culprit artery, global arterial tree morphology, internal jugular vein area, and meningeal lymphatic vessel volume. Associations between low-density lipoprotein cholesterol reduction and vascular metrics were analyzed using adjusted generalized additive models.
resultsAmong 24 enrolled patients, plaque burden at the site of maximal stenosis in the culprit artery decreased significantly (mean difference, -5.24% [95% CI, -9.25% to -1.23%]). Global arterial tree length (mean difference, 278.89 mm [95% CI, 26.60-531.18 mm]) and volume (mean difference, 411.38 mm
conclusionsThese findings reveal coordinated arterial and lymphatic changes beyond local plaque regression. Future studies are warranted to further explore these systemic changes and their clinical implications.
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