ArticleCell communication and signaling : CCS2026
8-gingerol from Zingiber officinale induces ER stress-mediated ferroptosis and apoptosis in ovarian cancer involving TRPV1 activation.
Article in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundOvarian cancer remains among the most lethal gynecological malignancies, primarily due to the persistent challenges of chemotherapy resistance and limited effectiveness of existing therapeutic strategies.
methodsTo evaluate the anti-tumor activity of 8-gingerol, its effects on cell viability, glutathione (GSH) levels, and the activities of caspase-3, lactate dehydrogenase (LDH), reactive oxygen species (ROS), and malondialdehyde (MDA) were examined in ovarian cancer cell lines. The underlying molecular mechanisms were investigated, involving the analysis of the TRPV1-PLCγ-NOX4 and PERK-ATF3-JMJD2C-SLC7A11-GPX4 signaling pathways. The functional role of ATF3 was further validated using gene knockdown approaches and promoter-binding assays. In addition, the in vivo therapeutic efficacy of 8-gingerol was assessed using a xenograft mouse model.
resultsTreatment with 8-gingerol significantly reduced cell viability and intracellular GSH levels, while increasing caspase-3 activity, LDH release, ROS generation, and MDA levels. These molecular and cellular effects were associated with marked inhibition of tumor growth in vivo. Mechanistically, 8-gingerol induced intracellular Ca
conclusionsThese findings demonstrate that 8-gingerol induces coordinated apoptotic and ferroptotic cell death through a Ca
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