ArticleActa neuropathologica communications2026
Integrated proteogenomic profiling reveals coordinated differential expression signatures during neuroinflammation.
Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundExperimental autoimmune encephalomyelitis (EAE) is a key model of autoimmune neuroinflammation, yet an integrated characterization of transcriptional and proteomic dysregulation of the CNS has been missing.
methodsIn this study, we performed deep proteogenomic profiling of the spinal cord from mice induced with EAE during acute disease by combining RNA-seq (GEO, GSE330115) and LC-MS/MS (PRIDE, PXD078146).
resultsWe identified extensive upregulation of innate and adaptive immune response signatures alongside concordant downregulation of neuronal, synaptic, and mitochondrial pathways. Despite expected divergence as reported in previous studies discussing neuroinflammation models, log₂ fold changes and pathway enrichment scores showed high concordance between both gene product levels (R
conclusionTogether, this integrated dataset reveals coordinated multilayer molecular remodelling in neuroinflammation and refines mechanistic interpretation of biomarker origin in inflamed CNS tissue in mice.
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