Evidence map›Paper›PMID 42432750›Full record

ArticleCell & bioscience2026

Genome-wide association and polygenic risk score analyses of MASLD-related hepatic steatosis severity in a Taiwanese Han population.

Ting-Yuan Liu, Jai-Sing Yang, Yu-Chia Chen, Shih-Chang Tsai, Yu-Jen Chiu, Chi-Chou Liao, Yen-Ting Chang, Woei-Cheang Shyu, Long-Bin Jeng, Fuu-Jen Tsai

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Article in Cell & bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Ting-Yuan Liu *Million-Person Precision Medicine Initiative, Department of Medical Research, China Medical University Hospital, Taichung, 40402, Taiwan.ORCID http://orcid.org/0000-0002-2729-0541
Jai-Sing Yang *Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan.
Yu-Chia ChenMillion-Person Precision Medicine Initiative, Department of Medical Research, China Medical University Hospital, Taichung, 40402, Taiwan.ORCID http://orcid.org/0000-0002-8837-6023
Shih-Chang TsaiDepartment of Biological Science and Technology, China Medical University, Taichung, 406040, Taiwan.
Yu-Jen ChiuDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Taipei Veterans General Hospital, Taipei, 112201, Taiwan.
Chi-Chou LiaoDepartment of Medical Research, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan.
Yen-Ting ChangMillion-Person Precision Medicine Initiative, Department of Medical Research, China Medical University Hospital, Taichung, 40402, Taiwan.
Woei-Cheang ShyuGraduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan.
Long-Bin JengCell Therapy Center, China Medical University Hospital, Taichung, 40402, Taiwan.
Fuu-Jen TsaiAI-Driven Genomic Medicine and Drug Discovery Lab, China Medical University Hospital, Taichung, 40402, Taiwan. 000704@tool.caaumed.org.tw.ORCID https://orcid.org/0000-0002-1373-245X

Funding

China Medical University Hospital DMR-115-127
6 · The paper itself

Abstract

backgroundHepatic steatosis is a highly prevalent metabolic condition and a major contributor to chronic liver disease, particularly in Asian populations. This study was conducted to identify genetic variants associated with the severity of ultrasound-defined hepatic steatosis in a Taiwanese Han population and evaluate the variants' biological relevance through cross-ancestry meta-analysis and functional validation.

methodsWe conducted a genome-wide association study (GWAS) of 133,895 individuals with data in the Genetic Biobank of China Medical University Hospital. Hepatic steatosis severity was graded on an ordinal scale (0-3) using standardised ultrasonographic criteria. The polygenic risk score (PRS) under continuous shrinkage (CS) approach was used to construct a PRS for genetic risk stratification across severity grades.

findingsIn the GWAS, we identified 1,229 single-nucleotide polymorphisms associated with hepatic steatosis severity (P < 1 × 10⁻

interpretationThis study delineates the genetic landscape of ultrasound-defined hepatic steatosis severity in a large Taiwanese Han population and demonstrates the robust ability of the PRS to predict disease stage.

Indexed as

Functional validationGenome-wide association study (GWAS)Hepatic steatosisPolygenic risk score (PRS)Taiwanese Han population

Identifiers

PMID42432750
PMCPMC13644211

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.