Evidence map›Paper›PMID 42432836›Full record

ArticleProtein science : a publication of the Protein Society2026

CoCryoViS: Collaborative online cryo-electron tomography visualization system.

Omar Mena, Uroš Šmajdek, Weiping Zhang, Piao Yu, Tobias Klein, Stefan T Arold, Sai Li, Ivan Viola, Ciril Bohak

Abstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. CoCryoViS: Collaborative online cryo-electron tomography visualization system.Protein science : a publication of the Protein Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Omar MenaKing Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia.ORCID 0009-0002-6564-0175
Uroš ŠmajdekFaculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia.ORCID 0000-0002-8127-7700
Weiping ZhangTsinghua University School of Life Sciences, Bejing, China.ORCID 0000-0002-6576-8358
Piao YuKing Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia.
Tobias KleinNanographics Gmbh, Wien, Austria.ORCID 0000-0001-9455-7587
Stefan T AroldKing Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia.ORCID 0000-0001-5278-0668
Sai LiTsinghua University School of Life Sciences, Bejing, China.ORCID 0000-0002-9353-0355
Ivan ViolaKing Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia.ORCID 0000-0003-4248-6574
Ciril BohakKing Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia.ORCID 0000-0002-1825-0097

Funding

Javna Agencija za Raziskovalno Dejavnost RS J250221King Abdullah University of Science and Technology 5932King Abdullah University of Science and Technology BAS/1/16800101
6 · The paper itself

Abstract

We present a collaborative, interactive, web-based visualization and processing system for Cryo-Electron Tomography (cryo-ET) data that supports the complete workflow, from raw tilt-series projections to final 3D segmentations. The system integrates tilt-series alignment, motion correction, tomographic reconstruction, manual and pseudo-annotation, deep model training, inference, and visualization, all accessible through a unified web-based interface. The backend manages computationally intensive tasks, including advanced tomographic reconstruction, pseudo-annotation generation, deep learning model training, and large-scale segmentation of new datasets. It features separate queues for CPU and GPU tasks, allowing users to prepare and manage large workloads in advance. The frontend supports lightweight tomographic reconstruction, manual data annotation, segmentation with pretrained models, interactive exploration of pipeline stages, and real-time monitoring of queued tasks. Key processing steps are available on both the client and server sides, providing flexibility for diverse computational environments, enabling visualization of externally hosted datasets, and supporting data privacy when required. The system is designed for collaborative workflows, enabling multiple users to share input data, annotations, and trained models within joint projects. Its modular architecture allows easy extension with additional stages on either the client or server side, making it adaptable to specialized pipelines within individual institutions. We demonstrate the system's capabilities on representative cryo-ET datasets, highlighting its utility for both individual researchers and distributed teams working on structural analysis of complex cellular environments. The initial release of the system is available at https://cocryovis.lgm.fri.uni-lj.si/ (Project repository: https://github.com/nanovis/cocryovis, mirror deploy: https://tomography.kaust.edu.sa/), and the entire system will become open source so that any visualization or domain researcher can further enhance its functionality.

Indexed as

Cryoelectron MicroscopyElectron Microscope TomographyImage Processing, Computer-AssistedSoftwareImaging, Three-DimensionalInternetcollaborative visualizationCryoETsegmentationtomographic reconstructionvolume visualizationWASMWebGPU

Identifiers

PMID42432836
PMCPMC13354744

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.