ArticleNeurobiology of stress2026
Activity of VMS-projecting mPFC neurons encodes individual vulnerability to chronic restraint stress in male mice.
Article in Neurobiology of stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The medial prefrontal cortex (mPFC) is critically involved in stress-related behaviors, specifically via the subpopulation of neurons that project to the ventromedial striatum (VMS). However, whether VMS-projecting mPFC neurons contribute to individual differences in behavioral responses to chronic stress remains unclear. Here, using a chronic restraint stress (CRS) model, we observed heterogeneous CRS-induced behavioral responses and stratified mice into relatively susceptible (SUS) and resilient (RES) subgroups based on a composite stress-related behavioral profile. To investigate the underlying neural basis, we performed
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