ArticleFrontiers in public health2026
Trajectories of grip strength decline and risk of new-onset cardiovascular disease: evidence from the HRS and ELSA cohorts.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Handgrip strength is an important indicator of overall health, yet most studies rely on single measurements. Evidence on its long-term trajectories and new-onset cardiovascular disease (CVD) risk remains limited. This study examined associations of baseline handgrip strength and its trajectories with new-onset CVD in two aging cohorts. Methods: Data were from the Health and Retirement Study (HRS) in the United States and the English Longitudinal Study of Ageing (ELSA). Participants aged ≥50 years without baseline CVD were included. Handgrip strength across three waves was used to construct trajectories via group-based trajectory modeling. Cox regression assessed associations with new-onset CVD. Fine-Gray models, discrete-time logistic regression, restricted cubic splines, and mediation analysis (depression) were conducted. Results: A total of 4,984 (HRS) and 4,982 (ELSA) participants were included. Over median follow-ups of 10 and 12 years, 1,438 and 1,184 CVD events occurred, respectively. Higher baseline handgrip strength was associated with lower CVD risk (HRS: HR = 0.79, 95% CI: 0.73-0.86; ELSA: HR = 0.83, 95% CI: 0.76-0.91). Two trajectories were identified: accelerated decline and steady decline. Compared with steady decline, accelerated decline was linked to higher CVD risk (HRS: HR = 1.44, 95% CI: 1.22-1.70; ELSA: HR = 1.31, 95% CI: 1.08-1.58). Results were consistent across sensitivity analyses. A linear inverse association was observed, and depression partially mediated this relationship. Conclusion: Lower baseline handgrip strength and accelerated decline are associated with increased CVD risk. Longitudinal monitoring may aid early risk identification and prevention.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.