ArticleQuantitative imaging in medicine and surgery2026
Preliminary exploration of quantitative analysis parameters of renal cortical blood perfusion by contrast-enhanced ultrasound in hypertensive patients.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Evaluation of renal blood perfusion is important for patients with hypertension. Contrast-enhanced ultrasound (CEUS) is a safe and non-invasive technique that allows semi-quantitative assessment of renal cortical perfusion. Using CEUS quantitative analysis, we aimed to employ the characteristics of renal cortical blood perfusion (RCBP) parameters in hypertension patients, providing objective evidence for quantifying the hemodynamic features of renal microcirculation. Methods: It was a single-center retrospective study that included data from 83 hypertensive patients without renal artery stenosis who underwent renal CEUS at the Department of Ultrasound Medicine, Beijing Hospital between October 2020 and June 2023. The study cohort comprised 45 males and 38 females. Data collected included patient height, weight, systolic and diastolic blood pressure, estimated glomerular filtration rate (eGFR), RCBP parameters, and other historical records. Through stratified analysis, the characteristics of RCBP parameters were analyzed for the left/right sides, different sexes, and elderly versus non-elderly individuals. Results: There were no statistically significant differences in all cortical blood flow perfusion parameters [peak intensity (PI); rise time (RT); mean transit time (MTT); area under the curve (AUC); wash-in area under the curve (iAUC); wash-out area under the curve (oAUC); time to peak (TTP); PI/MTT] between the right and left kidneys of the patients (P>0.05). The iAUC and TTP were greater in males than in females, with marginal statistical differences (both P<0.05). The MTT and TTP were greater in the elderly group than in the non-elderly group, whereas PI/MTT was greater in the non-elderly group, with marginal statistical differences (both P<0.05). The intraclass correlation coefficients (ICCs) and Bland-Altman plots demonstrated good inter-observer agreement for all cortical blood flow perfusion parameters, especially for time-related parameters. Conclusions: This study preliminarily investigated the characteristics of RCBP parameters in hypertensive patients, further validating good reproducibility of the quantitative analysis technique of contrast-enhanced ultrasound.
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