Evidence map›Paper›PMID 42433983›Full record

ArticleFrontiers in medicine2026

Persistent intrahepatic cholestasis secondary to multiple etiologies: a case report.

Ran Wang, Yiyang Shang, Cai'e Wang, Yanhong Gao, Wenxiu Zhang, Fangbo Gao, Yang Guo, Baocheng Deng, Wenwen Zhang, Xingshun Qi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ran Wang *Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, China.
Yiyang Shang *Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, China.
Cai'e Wang *Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, China.
Yanhong GaoDepartment of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, China.
Wenxiu ZhangDepartment of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, China.
Fangbo GaoDepartment of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, China.
Yang GuoDepartment of Blood Purification, General Hospital of Northern Theater Command, Shenyang, China.
Baocheng DengDepartment of Infectious Diseases, The First Affiliated Hospital, China Medical University, Shenyang, China.
Wenwen ZhangDepartment of Nuclear Medicine, General Hospital of Northern Theater Command, Shenyang, China.
Xingshun QiDepartment of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrahepatic cholestasis may arise from multiple etiologies, but it is particularly challenging to identify its primary etiology, especially when several potential contributors overlap and the disease itself progresses over time. Herein, we report a 42-year-old man with adult-onset Still's disease (AOSD) who developed persistent severe intrahepatic cholestasis. At early stage of this disease, intrahepatic cholestasis was attributed to severe liver injury secondary to AOSD and drug-induced liver injury. Subsequently, sepsis developed, which might be associated with the use of glucocorticoids and contamination of central venous catheter, and aggravated intrahepatic cholestasis. Finally, the patient's condition was gradually improved after catheter removal and targeted antibiotic therapy. This case highlights the importance of etiological reassessment in the management of persistent intrahepatic cholestasis.

Indexed as

adult-onset Still’s diseaseglucocorticoidsintrahepatic cholestasisliver biopsysepsissevere liver injury

Identifiers

PMID42433983
PMCPMC13352411

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.