Evidence map›Paper›PMID 42434054›Full record

ArticleJournal of surgical case reports2026

Exacerbated oral pyogenic granuloma in type 2 diabetes mellitus and advanced periodontitis: clinical management and pathophysiological insights: a case report.

Francisco Javier Alcaraz-Baturoni, Jessica Paola Ibarra-González, Luis Fernando López-Hernández, Mario Alberto Alarcón-Sánchez, Daniel Ortuño-Sahagún, Artak Heboyan, Juan Pablo González-Cárdenas, Sarah Monserrat Lomelí-Martínez

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francisco Javier Alcaraz-BaturoniDepartment of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Calle Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco, Mexico.
Jessica Paola Ibarra-GonzálezDepartment of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Calle Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco, Mexico.
Luis Fernando López-HernándezDepartment of Microbiology and Pathology, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Calle Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco, Mexico.
Mario Alberto Alarcón-SánchezMolecular Biology and Medicine Program, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG), Calle Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco, Mexico.
Daniel Ortuño-SahagúnLaboratory of Molecular Neuroimmunobiology, Institute of Translational Neurosciences, Department of Molecular Biology and Genomics, University Center for Health Sciences, University of Guadalajara (CUCS-UdeG), Calle Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco, Mexico.
Artak HeboyanDepartment of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, India.ORCID https://orcid.org/0000-0001-8329-3205
Juan Pablo González-CárdenasDepartment of Medical and Life Sciences, La Ciénega University Center, University of Guadalajara (CUCIENEGA-UdeG), Avenida Universidad 1115, Colonia Lindavista, Ocotlán 47810, Jalisco, Mexico.
Sarah Monserrat Lomelí-MartínezDepartment of Medical and Life Sciences, La Ciénega University Center, University of Guadalajara (CUCIENEGA-UdeG), Avenida Universidad 1115, Colonia Lindavista, Ocotlán 47810, Jalisco, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral pyogenic granuloma (OPG) is a benign vascular proliferation that presents as a solitary, pedunculated, or sessile lesion, associated with irritative factors. Various systemic disorders, particularly type 2 diabetes mellitus (DM2), may contribute to its onset and progression through inflammatory and endothelial mechanisms. This clinical case report describes a 63-year-old male with a history of controlled hypertension and DM2 with glycated hemoglobin (HbA1c) of 7.97%, diagnosed with stage III, grade C generalized periodontitis. Therapeutic management began with periodontal phase I, including personalized oral hygiene instructions and scaling and root planning. After re-evaluation at 5 weeks, an excisional biopsy of the hyperplastic lesion was performed. Histopathological analysis confirmed OPG. The postoperative course was favorable, with proper healing at 15 days. Recent studies indicate that T2DM exacerbates periodontal inflammation through advanced glycation end-products and receptor for advanced glycation end-products (RAGE) signaling, accelerating OPG progression. Multidisciplinary approaches, including glycemic optimization, improve outcomes in these comorbidities.

Indexed as

capillary hemangiomacase reportdiabetes mellitushyperplastic lesionperiodontitispyogenic granuloma

Identifiers

PMID42434054
PMCPMC13349868

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.