Evidence mapPaperPMID 42434334Full record

ReviewJournal of pharmaceutical analysis2026

Targeting angiogenesis in diabetic wound healing: New insight from chemical architecture to functional outcomes.

Junren Chen, Siqi Qin, Ziwei Xing, Cheng Peng, Dan Li

Abstract readReview
In one paragraph

Review in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Junren ChenState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Siqi QinState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Ziwei XingState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Cheng PengState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Dan LiState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic wound healing (DWH) is a multifaceted process hindered by impaired angiogenesis that usually leads to increased risks of infection and amputation. Targeting impeded angiogenic signals to restore the microenvironment favoring vascular network re-establishment is a promising therapeutic strategy for diabetic wound. Natural products have emerged as potential therapeutic agents for diabetic wounds by regulating endotheliocytes functions and their cross-talks with immune cells and fibroblasts, while the similarities and differences of the chemical structures greatly determine their distinct efficient and underlying mechanisms in diabetic wound angiogenesis. In this review, relevant literature was retrieved from PubMed, Google Scholar, and Web of Science databases, covering publications from 2020 to 2025. This paper reviews the role of angiogenesis in DWH and the action of natural products in DWH by targeting angiogenesis, particularly highlighting their chemical architecture driven specific biological activity on angiogenesis, with the aim of providing references for angiogenesis-based therapeutic strategies for diabetic ulcers and promoting the development of angiogenesis-targeting agents.

Indexed as

AngiogenesisDiabetic wound healingEndothelial cellsNatural productsStructure-activity relationships

Identifiers

PMID42434334
PMCPMC13352021

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.