ArticleJournal of oral biology and craniofacial research
Inflammation mediated Osteoclastogenesis and bone resorption markers in Periodontitis subjects with and without type 2 diabetes- A Cross-sectional study.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Periodontitis and type2 diabetes are chronic inflammatory diseases resulting in osteoclastogenesis and bone loss Methods: Whole blood samples were collected from periodontitis subjects with (n = 30) or without T2D (n = 30) and healthy subjects (n = 30). Isolated PBMCs were cultured to study osteoclastogenesis pathways Results: Our results showed that cultured PBMCs from periodontitis and T2D subjects demonstrated a higher number of TRAP positive cells compared to subjects without T2D. IL6, CTx and TRAP5b levels were significantly elevated in T2D with periodontitis, compared to normal subjects with or without periodontitis. Conclusion: This study provides insights on inflammation mediated bone remodelling T2D in periodontitis leading to alveolar bone loss. Understanding this molecular mechanism might provide future translational potential and therapeutic interventions for the osteoclast-related pathological bone diseases such as chronic periodontitis, enabling prevention of tooth loss.
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