ArticleFrontiers in aging neuroscience2026
Regional brain and cerebrovasculature morphology during normative aging in male and female C57BL/6N mice.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Introduction: Normative aging is the process of gradual physical, cognitive and biological changes that occur with advancing age. This contrasts to pathological processes, such as neurodegeneration where changes are accelerated and more pronounced. Brain morphology and its cerebrovasculature are known to progressively alter during normative human and rodent lifespan. Methods: We assessed regional brain volumes (morphology) and cerebrovasculature characteristics across three lifespan epochs (6, 18, and 26 months of age) in male and female C57BL/6N mice, a widely used strain. The cerebrovasculature was assessed in mice using a vessel staining method we call vessel painting. High resolution magnetic resonance imaging (MRI) was acquired Results: While no overt changes in cortical vasculature were detected across age or sex, we observed age-related changes in total and regional brain volumes. Selected brain regions exhibited sex-specific alterations. Conclusion: Our study reports regional brain changes across the lifespan in an age- and sex-dependent manner in C57BL/6N mice.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.