Evidence map›Paper›PMID 42434731›Full record

ArticleMaterials today. Bio2026

Fuel-maintenance coupling reprograms mitochondrial homeostasis to enable peripheral nerve regeneration.

Jun-Kuan Shan, Jia-Qi Fang, Xue-Han Jin, Bo Xu, Li-Ping Nan, Zhi-Jie Weng, Shu-Hao Liu, Xin-Hui Wu, Zhong Wu, Jun-Jian Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jun-Kuan ShanDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 301 Yanchang Road, Shanghai, 200072, PR China.
Jia-Qi FangDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 301 Yanchang Road, Shanghai, 200072, PR China.
Xue-Han JinDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 301 Yanchang Road, Shanghai, 200072, PR China.
Bo XuDepartment of Orthopedics, the First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Bengbu, Anhui Province, 233004, PR China.
Li-Ping NanDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 301 Yanchang Road, Shanghai, 200072, PR China.
Zhi-Jie WengDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 301 Yanchang Road, Shanghai, 200072, PR China.
Shu-Hao LiuDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 301 Yanchang Road, Shanghai, 200072, PR China.
Xin-Hui WuDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 301 Yanchang Road, Shanghai, 200072, PR China.
Zhong WuDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 301 Yanchang Road, Shanghai, 200072, PR China.
Jun-Jian LiuDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 301 Yanchang Road, Shanghai, 200072, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral nerve regeneration is frequently stalled by a "metabolic bottleneck" characterized by mitochondrial dysfunction and bioenergetic exhaustion. Although nerve guidance conduits (NGCs) provide structural support, most remain metabolically inactive and fail to address this energetic deficit. Here, we developed a fuel-maintenance coupling metabolic reprogramming strategy to support peripheral nerve repair. A biomimetic NGC was engineered with an aligned electrospun polycaprolactone (PCL) sheath filled with an injectable,

Indexed as

Autophagy activationMagnololMitochondrial repairPeripheral nerve regenerationα-lipoic acid

Identifiers

PMID42434731
PMCPMC13351185

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.