Evidence map›Paper›PMID 42435142›Full record

ReviewCardiovascular toxicology2026

The mtROS-Mitophagy Axis: A Decisive Redox Hub Governing Cell Fate in Myocardial Ischemia-Reperfusion Injury.

Wei Wang, Zhihao Xu, Wei Liu, Yaolu Kang, Fan Zhang, Qing Yu, Ronglin Cai

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cardiovascular toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wei WangScience and Technology Department, Anhui University of Chinese Medicine, Hefei, 230012, China.
Zhihao XuCollege of Acupuncture and Moxibustion, Anhui University of Chinese Medicine, Hefei, 230012, China.
Wei LiuCollege of Acupuncture and Moxibustion, Anhui University of Chinese Medicine, Hefei, 230012, China.
Yaolu KangCollege of Acupuncture and Moxibustion, Anhui University of Chinese Medicine, Hefei, 230012, China.
Fan ZhangCollege of Acupuncture and Moxibustion, Anhui University of Chinese Medicine, Hefei, 230012, China.
Qing YuCollege of Acupuncture and Moxibustion, Anhui University of Chinese Medicine, Hefei, 230012, China. yuqingtcm@126.com.
Ronglin CaiCollege of Acupuncture and Moxibustion, Anhui University of Chinese Medicine, Hefei, 230012, China. ronglincai@ahtcm.edu.cn.

Funding

Excellent Youth Scientific Research Project in Universities of Anhui Province 2022AH030062he National Natural Science Foundation of China 82575235, 82074536the Distinguished Youth Scientific Research Project in Universities of Anhui Province 2022AH020043the National Natural Science Foundation of China 82104999
6 · The paper itself

Abstract

The progression of myocardial ischemia-reperfusion injury (MIRI) is orchestrated by a decisive, bidirectional dialogue between mitochondrial reactive oxygen species (mtROS) and mitophagy. This review advances the concept of a dynamic "mtROS-mitophagy axis" as the central redox hub determining cardiomyocyte fate. We systematically dissect how moderate mtROS initiates protective mitophagy via key pathways (e.g., PINK1/Parkin, FUNDC1) and reinforces endogenous defenses through the Sirt3-FoxO3a integrator. Conversely, an mtROS burst disrupts this axis, triggering a vicious cycle of oxidative damage, impaired autophagic flux, and Drp1-mediated pathological fission. Critically, we emphasize the double-edged and temporally governed nature of this axis, arguing that its precise spatiotemporal modulation represents the next frontier in cardioprotection. Beyond mechanism, this synthesis provides a unified framework for developing novel therapies and for evaluating the cardiac safety of pharmacological agents, directly aligning with the core pursuits of cardiovascular redox biology and toxicology.

Indexed as

Mitochondria, HeartMitophagyMyocardial Reperfusion InjuryMyocytes, CardiacOxidative StressReactive Oxygen SpeciesAnimalsHumansOxidation-ReductionSignal TransductionReactive Oxygen SpeciesAntioxidant defenseMitochondrial reactive oxygen speciesMitophagyMyocardial ischemia-reperfusion injuryOxidative stressRedox signalingSirt3

Identifiers

PMID42435142

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.