ReviewAdvances in experimental medicine and biology2026
Epigenetics and One-Carbon Metabolism in Cancer: Mechanisms and Therapeutic Implications.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetics refers to heritable changes in gene expression that occur without alterations in the DNA sequence itself, primarily through mechanisms such as DNA methylation and histone modifications. These regulatory processes are essential for normal development, cellular differentiation, and genome stability. In cancer, however, epigenetic reprogramming becomes dysregulated, contributing to tumor initiation, progression, and metastasis. Aberrant DNA methylation patterns and histone modifications can silence tumor suppressor genes or activate oncogenes, driving malignant transformation. Central to these epigenetic processes is one-carbon metabolism-a biochemical network that supplies methyl groups for DNA and histone methylation through metabolites such as S-adenosylmethionine (SAM). As such, the interplay between one-carbon metabolism and epigenetic regulation is a critical axis in understanding and potentially targeting cancer biology.
Indexed as
Identifiers
42435173What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.