Evidence map›Paper›PMID 42435183›Full record

ReviewAdvances in experimental medicine and biology2026

Mass Spectrometry as a Tool for Metabolomics in Cancer.

João S Patrício, Ana C L Guerreiro, Paulo A Gameiro, Judit Morello

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

João S PatrícioiNOVA4Health, NOVA Medical School | Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Lisboa, Portugal.
Ana C L Guerreiro *iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12,, 2781-901, Oeiras, Portugal.
Paulo A Gameiro *iNOVA4Health, NOVA Medical School | Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Lisboa, Portugal.
Judit Morello *iNOVA4Health, NOVA Medical School | Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Lisboa, Portugal. judit.morello@nms.unl.pt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mass spectrometry (MS) is a highly sensitive and high-throughput analytical technology that has become central to investigating the metabolic alterations in cancer cells, enabling the discovery of diagnostic biomarkers and potential therapeutic targets. This chapter provides an overview of the key principles of MS-based metabolomics, covering the entire experimental workflow-from sample collection and preparation to data acquisition, preprocessing, normalization, statistical modeling, and pathway enrichment analysis. We also discuss current limitations and outline future directions to enhance data reproducibility, metabolite annotation, and clinical translation of MS-based results.

Indexed as

Biomarkers, TumorMass SpectrometryMetabolomeMetabolomicsNeoplasmsAnimalsHumansBiomarkers, TumorBiomarkersCancer diagnosisMass spectrometry (MS)MS-based metabolomics

Identifiers

PMID42435183

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.