ArticleMagma (New York, N.Y.)2026
Evaluation of high-fat diet-induced metabolic impairments in iBAT lipid metabolism using
Article in Magma (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHigh-fat diet (HFD) feeding impairs interscapular brown adipose tissue (iBAT) mitochondrial function, leading to lipid accumulation and insulin resistance.
objectiveTo evaluate HFD-induced metabolic impairments in iBAT lipid metabolism using MATERIALS AND
methodsMale Wistar rats (n = 20) were fed either chow diet (CD) or HFD for eight weeks followed by maintained thermoneutral or cold-exposed conditions for two weeks. Lipid content in iBAT was quantified by localized
resultsAt thermoneutrality, HFD-fed animals showed increased iBAT lipid fraction (75.3 ± 2% vs. 63.3 ± 1.7%, p < 0.05), elevated plasma glucose and insulin and downregulated UCP1, ATGL, CPT1, and PGC-1α (p < 0.01), indicating impaired oxidative metabolism. Cold exposure significantly reduced iBAT lipid in both CD and HFD groups (p < 0.01) and upregulated functional genes (p < 0.001), restoring mitochondrial functions, lipid oxidation, and thermogenic activity.
conclusionHFD feeding caused insulin resistance and impaired iBAT mitochondrial functions and thermogenic activity, due to lipid accumulation. Chronic cold exposure improved insulin sensitivity and restored iBAT oxidative metabolism and mitochondrial functions.
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