Evidence map›Paper›PMID 42435583›Full record

Observational studyEBioMedicine2026

Integrated immune and endothelial profiling predicts 90-day mortality in postoperative sepsis and septic shock.

Rosa Dolores Prieto-Utrera, Miguel Bardají-Carrillo, Esther Gómez-Sánchez, Rosa Cobo-Zubia, Irina Rebollo-Mato, Marina Perez-Mazzali, Jessica Matesanz-Isabel, Laura Sánchez-de Prada, Álvaro Tamayo-Velasco, Marta Martín-Fernández and 17 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Rosa Dolores Prieto-UtreraGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Institute of Health Sciences of Castile and Leon (ICSCYL), Soria, Spain; Research Unit, University Clinical Hospital of Valladolid, Spain.
Miguel Bardají-CarrilloGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain.
Esther Gómez-SánchezGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Surgery, Faculty of Medicine, University of Valladolid, Valladolid, Spain.
Rosa Cobo-ZubiaGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Institute of Health Sciences of Castile and Leon (ICSCYL), Soria, Spain; Research Unit, University Clinical Hospital of Valladolid, Spain.
Irina Rebollo-MatoGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Research Unit, University Clinical Hospital of Valladolid, Spain; Department of Pharmacology, Faculty of Medicine, University of Valladolid, Valladolid, Spain.
Marina Perez-MazzaliMucosal Immunology Laboratory, Institute of Biomedicine and Molecular Genetics from Valladolid (IBGM, University of Valladolid, CSIC), Valladolid, Spain.
Jessica Matesanz-IsabelGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Institute of Health Sciences of Castile and Leon (ICSCYL), Soria, Spain; Research Unit, University Clinical Hospital of Valladolid, Spain.
Laura Sánchez-de PradaGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; National Influenza Centre, Valladolid, Spain.
Álvaro Tamayo-VelascoGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Hematology and Hemotherapy, University Clinical Hospital of Valladolid, Valladolid, Spain; Department of Medicine, Faculty of Medicine, University of Valladolid, Valladolid, Spain. Electronic address: alvaro.tamayo@uva.es.
Marta Martín-FernándezGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Pharmacology, Faculty of Medicine, University of Valladolid, Valladolid, Spain.
María Sherezade Tovar-DoncelGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Toledo, Toledo, Spain.
Peter AdamoveDepartment of Anesthesiology and Critical Care, Clinical Hospital of Bellvitge, Barcelona, Spain.
Elena Carrasco-SerranoGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain.
Sara Cocho-CrespoGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain.
Ana Fernández-UrbonGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain.
María Fernández-ArranzGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain.
José M EirosBiomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Microbiology, Río Hortega University Hospital, Valladolid, Spain; National Influenza Centre, Valladolid, Spain; Department of Microbiology, Faculty of Medicine, Universidad de Valladolid, Spain; Department of Microbiology, University Clinical Hospital of Valladolid, Valladolid, Spain.
Iván Sanz-MuñozInstitute of Health Sciences of Castile and Leon (ICSCYL), Soria, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; National Influenza Centre, Valladolid, Spain.
Hugo Gonzalo-BenitoGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Institute of Health Sciences of Castile and Leon (ICSCYL), Soria, Spain; Research Unit, University Clinical Hospital of Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain.
Rocío López-HerreroGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Surgery, Faculty of Medicine, University of Valladolid, Valladolid, Spain.
Gerardo AguilarBiomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valencia, Valencia, Spain; Faculty of Medicine, University of Valencia, Valencia, Spain.
Roberto HorneroBiomedical Engineering Group, University of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Carlos III Health Institute, Madrid, Spain.
Can InceDepartment of Intensive Care, Laboratory of Translational Intensive Care, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Rodrigo Poves-ÁlvarezGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Surgery, Faculty of Medicine, University of Valladolid, Valladolid, Spain.
David BernardoBiomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Mucosal Immunology Laboratory, Institute of Biomedicine and Molecular Genetics from Valladolid (IBGM, University of Valladolid, CSIC), Valladolid, Spain.
Eduardo TamayoGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Department of Anesthesiology and Critical Care, University Clinical Hospital of Valladolid, Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain; Department of Surgery, Faculty of Medicine, University of Valladolid, Valladolid, Spain.
Adrián García-ConcejoGroup for Biomedical Research in Critical Care (BioCritic), Valladolid, Spain; Biomedical Research Networking Center in Infectious Diseases (CIBERINFEC), Carlos III Health Institute, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSepsis and septic shock remain major causes of mortality in critically ill postoperative patients, largely because of the lack of reliable biomarkers for early risk stratification. The interplay between immune dysfunction and endothelial activation is key in the progression to multiorgan failure, however phenotypic characterisation of circulating endothelial subpopulations remains limited.

methodsA Prospective multicentre study included 219 postoperative patients (Non-septic ICU patients, sepsis, septic shock). Peripheral Blood Mononuclear Cells were analysed using high-dimensional spectral flow cytometry. Both supervised gating strategies and high-dimensional unsupervised analyses (UMAP and FlowSOM) were applied to identify immune and endothelial cell subsets. Associations with 90-day mortality were assessed using univariate and multivariate Cox proportional hazards models, refined with LASSO-Cox regression, and integrated into a risk score. The predictive performance of this cellular risk score was compared with SOFA and APACHE II scores using ROC curves and survival analysis. Findings were further validated using publicly available single-cell RNA datasets.

findingsTwo B cell subsets (plasmablasts/IgG

interpretationThe combination of immune and endothelial profiling provides a robust cellular signature that improves the prognostic stratification in postoperative sepsis. These biomarkers may support treatment and guide therapeutic strategies aimed at restoring immune-endothelial homoeostasis.

fundingThis work was supported by the Instituto de Salud Carlos III [grant numbers: PI24/00754, FI25/00242 and CIBERINFEC CB21/13/00051], Junta de Castilla y León [GRS 2782/A2/2023, GRS 2804/A1/2023].

Indexed as

Endothelial CellsPostoperative ComplicationsSepsisAgedBiomarkersCritical IllnessFemaleHumansMaleMiddle AgedPrognosisProspective StudiesROC CurveShock, SepticBiomarkersBiomarkersEndotheliumFlow cytometryImmune systemSepsis

Identifiers

PMID42435583
PMCPMC13382015

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.