Evidence map›Paper›PMID 42435771›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression.

Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ruijiang ZengDepartment of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Mengmeng WangCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Kang WangDepartment of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, P. R. China.
Zhuo XingDepartment of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID https://orcid.org/0009-0008-8721-4488
Yulong HongDepartment of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Tongtong LiCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Geng ZongCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Chong YangDepartment of Hepatobiliary and Pancreas Surgery, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Dan ZhangCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0000-0001-6277-2100
Zhangling ChenDepartment of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, P. R. China.
Xin JinDepartment of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Funding

Central South University Innovation-Driven Research Program 2023CXQD058Chinese National Natural Science Foundation 82073321Chinese National Natural Science Foundation 82203814Chinese National Natural Science Foundation 82272910Chinese National Natural Science Foundation 82473229Excellent Youth Foundation of Hunan Scientific Committee 2022JJ10092Hunan leading program for science and technology innovation of high technology industries 2022GK4020Hunan Provincial Natural Science Foundation for Young Scholars (Class A) Continuation Project 2026j20010Key scientific research project of Hunan Provincial Health Commission W20242004Science and Technology Research Project of Furong Laboratory 2025PT5001
6 · The paper itself

Abstract

Psychological stress, particularly depression, is increasingly recognized as a non-genetic determinant of cancer progression, yet its role in hepatocellular carcinoma (HCC) remains unclear. By integrating three prospective cohorts (CHARLS, NHANES, and UK Biobank; n = 492,501), we show that depression was associated with increased HCC risk (CHARLS: hazard ratio (HR) = 2.28, 95% confidence interval (CI) 1.06-4.93; NHANES: odds ratio (OR) = 5.95, 95% CI 2.42-14.0; UK Biobank: HR = 1.39, 95% CI 1.10-1.79). Using patient samples, multi-omics analyses, and social isolation (SI) models, we identified taurocholate as a key metabolite elevated in psychological stress-associated HCC. Taurocholate stabilizes CBX5 by weakening its interaction with E3 ubiquitin ligases. CBX5 cooperated with MYC to activate PHGDH transcription, thereby reducing ferroptotic sensitivity and promoting tumor growth. Importantly, ursodeoxycholic acid (UDCA), a clinically approved bile acid modulator, reduced taurocholate levels and suppressed tumor growth in SI-associated HCC models. Together, these findings support a mechanistic link between depression and HCC progression via bile acid metabolic reprogramming and identify the taurocholate-CBX5-MYC-PHGDH axis as a potential therapeutic target.

Indexed as

CBX5ferroptosispsychological stresssocial isolationtaurocholate

Identifiers

PMID42435771
PMCPMC13355934

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.