Evidence map›Paper›PMID 42436276›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Is abnormal brain insulin action implicated in the biology of depression? A pilot neuroimaging study in adolescents.

Kateryna Maksyutynska, Nicolette Stogios, Vittal Korann, Laurie Hamel, Daphne Korczak, Benjamin I Goldstein, Gary Remington, Marcos Sanches, Margaret K Hahn, Ariel Graff-Guerrero and 1 more

Abstract read
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In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kateryna MaksyutynskaSchizophrenia Division, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.ORCID http://orcid.org/0009-0001-8848-4171
Nicolette StogiosSchizophrenia Division, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-9136-4923
Vittal KorannSchizophrenia Division, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Laurie HamelSchizophrenia Division, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Daphne KorczakInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.
Benjamin I GoldsteinDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-0340-349X
Gary RemingtonSchizophrenia Division, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Marcos SanchesKrembil Centre for Neuroinformatics, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Margaret K HahnSchizophrenia Division, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-8884-9946
Ariel Graff-GuerreroInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.
Sri Mahavir AgarwalSchizophrenia Division, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada. Mahavir.Agarwal@camh.ca.ORCID http://orcid.org/0000-0002-2705-5146

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain insulin action was measured in adolescents with (cases) and without (controls) depression, by calculating the difference in resting-state functional connectivity (ΔrsFC) following an intranasal insulin challenge. A significant Group × Condition interaction effect was identified: controls exhibited greater ΔrsFC with intranasal insulin compared to cases in brain regions regulating cognitive/emotional processing.

Identifiers

PMID42436276

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.