Evidence map›Paper›PMID 42436349›Full record

ArticleRice (New York, N.Y.)2026

A FtsH-Like Zinc Metalloprotease, OsFtsH1, Coordinates Chloroplast Development and Photosystem II Homeostasis in Rice.

Kangwei Liu, Qiao Yu, Haiyang Feng, Mengna Wang, Qiang Dai, Jiayi Chang, Chao Zhang, Hengxiu Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rice (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kangwei LiuJiangsu Key Laboratory of Crop Genomics and Molecular Breeding, Zhongshan Biological Breeding Laboratory, Key Laboratory of Plant Functional Genomics of the Ministry of Education, Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, Agricultural College of Yangzhou University, Yangzhou, China.
Qiao YuJiangsu Key Laboratory of Crop Genomics and Molecular Breeding, Zhongshan Biological Breeding Laboratory, Key Laboratory of Plant Functional Genomics of the Ministry of Education, Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, Agricultural College of Yangzhou University, Yangzhou, China.
Haiyang FengJiangsu Key Laboratory of Crop Genomics and Molecular Breeding, Zhongshan Biological Breeding Laboratory, Key Laboratory of Plant Functional Genomics of the Ministry of Education, Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, Agricultural College of Yangzhou University, Yangzhou, China.
Mengna WangJiangsu Key Laboratory of Crop Genomics and Molecular Breeding, Zhongshan Biological Breeding Laboratory, Key Laboratory of Plant Functional Genomics of the Ministry of Education, Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, Agricultural College of Yangzhou University, Yangzhou, China.
Qiang DaiJiangsu Key Laboratory of Crop Genomics and Molecular Breeding, Zhongshan Biological Breeding Laboratory, Key Laboratory of Plant Functional Genomics of the Ministry of Education, Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, Agricultural College of Yangzhou University, Yangzhou, China.
Jiayi ChangJiangsu Key Laboratory of Crop Genomics and Molecular Breeding, Zhongshan Biological Breeding Laboratory, Key Laboratory of Plant Functional Genomics of the Ministry of Education, Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, Agricultural College of Yangzhou University, Yangzhou, China.
Chao ZhangJiangsu Key Laboratory of Crop Genomics and Molecular Breeding, Zhongshan Biological Breeding Laboratory, Key Laboratory of Plant Functional Genomics of the Ministry of Education, Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, Agricultural College of Yangzhou University, Yangzhou, China. chaozhang@yzu.edu.cn.
Hengxiu YuJiangsu Key Laboratory of Crop Genomics and Molecular Breeding, Zhongshan Biological Breeding Laboratory, Key Laboratory of Plant Functional Genomics of the Ministry of Education, Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, Agricultural College of Yangzhou University, Yangzhou, China. hxyu@yzu.edu.cn.

Funding

Jiangsu Funding Program for Excellent Postdoctoral Talent 2025ZB610National Key Research and Development Program of China 2022YFD1200103National Natural Science Foundation of China 32370901Priority Academic Program Development of Jiangsu Higher Education Institutions PAPD
6 · The paper itself

Abstract

Chloroplast development is a fundamental process underlying photosynthesis and plant growth, yet its molecular regulatory mechanisms remain to be fully elucidated. In this study, we identified an albino rice mutant, which exhibits drastically reduced chlorophyll content and defective chloroplast ultrastructure. Through map-based cloning, coupled with CRISPR/Cas9-mediated gene editing and complementation assays, we verified that the target gene encodes a zinc metalloprotease of the FtsH protein family, OsFtsH1. The expression of OsFtsH1 is light-inducible, and its encoded protein localizes specifically to chloroplasts. RNA-sequencing (RNA-seq) analysis revealed broad differential expression of photosynthesis-related genes in osftsh1 mutants. qRT-PCR further demonstrated that plastid-encoded genes involved in chloroplast biogenesis are markedly downregulated at the transcriptional level. Functional assays indicated that OsFtsH1 sustains the homeostasis of D1, D2 and CP43, core proteins of the photosystem II (PSII), and collaboratively regulates chloroplast development through interactions with three key proteins: the chloroplast signaling protein OsCPL1, the PSII oxygen-evolving complex component OsPsbO, and the photosynthetic electron transport protein OsFd1. Additionally, the expression of OsFtsH1 is induced by indole-3-acetic acid (IAA) and abscisic acid (ABA), and its overexpression markedly enhances rice sensitivity to these two phytohormones. Collectively, our findings unravel the multifaceted and crucial functions of OsFtsH1 in orchestrating chloroplast development, photosynthetic machinery homeostasis, and stress response in rice.

Identifiers

PMID42436349
PMCPMC13642237

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.