Evidence map›Paper›PMID 42436366›Full record

ArticleBMC genomics2026

Bioinformatics analysis of the sodium-dependent neurotransmitter transporter family in Bursaphelenchus xylophilus.

Caijin He, Shichao Wang, Haixiang Li, Na Pu, Wangyang Liao, Jie Chen, Xin Hao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Caijin HeYunnan Key Laboratory of Forest Disaster Warning and Control, Southwest Forestry University, Kunming, 650224, China.
Shichao WangYunnan Key Laboratory of Forest Disaster Warning and Control, Southwest Forestry University, Kunming, 650224, China.
Haixiang LiKey Laboratory of National Forestry and Grassland Administration On Prevention and Control Technology of Pine Wilt Disease, Anhui Academy of Forestry, Hefei, 230088, China.
Na PuYunnan Key Laboratory of Forest Disaster Warning and Control, Southwest Forestry University, Kunming, 650224, China.
Wangyang LiaoKey Laboratory of National Forestry and Grassland Administration On Prevention and Control Technology of Pine Wilt Disease, Anhui Academy of Forestry, Hefei, 230088, China.
Jie ChenYunnan Key Laboratory of Forest Disaster Warning and Control, Southwest Forestry University, Kunming, 650224, China. jiechen@swfu.edu.cn.
Xin HaoYunnan Key Laboratory of Forest Disaster Warning and Control, Southwest Forestry University, Kunming, 650224, China. xinhao@swfu.edu.cn.

Funding

Key Laboratory of National Forestry and Grassland Administration on Prevention and Control Technology of Pine Wilt Disease 202501Southwest Forestry University Forestry major in Yunnan Province First-Class Construction Discipline LXXK-2023M06, LXXK-2024Z04Yunnan Fundamental Research Projects 202401BD070001-115
6 · The paper itself

Abstract

Pine wilt disease (PWD), caused by Bursaphelenchus xylophilus, poses a significant threat to global pine forests. The sodium-dependent neurotransmitter transporter (SNF) plays a critical role in the reuptake of neurotransmitters from the synaptic cleft, thereby terminating neural signal transmission and maintaining nervous system homeostasis. This study aimed to comprehensively identify all members of the SNF in B. xylophilus and elucidated their roles in nematode development and nervous system function. Through genome-wide data analysis, we identified 18 SNFs in B. xylophilus and thoroughly characterized their physicochemical properties, conserved motifs, protein structures, and gene expression profiles across different developmental stages. Phylogenetic analysis revealed evolutionary relationships with SNF homologs from other nematodes, suggesting lineage-specific functional adaptations. Chromosomal localization revealed that the SNF genes are distributed across five chromosomes with numbers ranging from 1 to 18. Expression analysis showed that Bx-snf-2, Bx-snf-6, Bx-snf-7, Bx-snf-9, Bx-snf-10 were highly expressed in adult males, while Bx-snf-1 and Bx-snf-4 were enriched during the egg stage. Additionally, Bx-snf-12 and Bx-snf-18 exhibited peak expression in fourth-stage larvae (L4). Notably, the upregulation of specific Bx-snfs during the dauer stage indicates potential roles in mediating stress adaptation and survival under adverse conditions. This study provides the first systematic characterization of the BxSNFs, revealing unique gene structures and specialized expression profiles. These findings offer potential molecular targets for developing novel control strategies against pine wilt disease by interfering with neurotransmitter reuptake.

Indexed as

Computational BiologyHelminth ProteinsNeurotransmitter Transport ProteinsSodiumTylenchidaAnimalsEvolution, MolecularGene Expression ProfilingMultigene FamilyPhylogenyHelminth ProteinsNeurotransmitter Transport ProteinsSodiumBioinformatics analysisBursaphelenchus xylophilusGene familySodium neurotransmitter cotransporter

Identifiers

PMID42436366
PMCPMC13640315

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.