Evidence map›Paper›PMID 42436582›Full record

ArticleJournal of translational medicine2026

Inhibition of p65 nuclear translocation in decidual stromal cells underlies COS-induced supraphysiologic estrogen impairment of uNK cell function which drives placental abnormalities.

Haikun Yu, Hui Mu, Yujing Xiong, Jiaqin Mao, Hui Lei, Xueyan Lu, Jie Dong, Ni Jin, Jie Lu, Shuqiang Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haikun Yu *Reproductive Medicine Center, Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710000, China.
Hui Mu *Reproductive Medicine Center, Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710000, China.
Yujing XiongReproductive Medicine Center, Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710000, China.
Jiaqin MaoReproductive Medicine Center, Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710000, China.
Hui LeiReproductive Medicine Center, Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710000, China.
Xueyan LuReproductive Medicine Center, Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710000, China.
Jie DongReproductive Medicine Center, Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710000, China.
Ni JinReproductive Medicine Center, Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710000, China.
Jie LuReproductive Medicine Center, Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710000, China.
Shuqiang ChenReproductive Medicine Center, Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710000, China. chenshuqiang2012@163.com.
Xiaohong WangReproductive Medicine Center, Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, No.1, Xinsi Road, Baqiao District, Xi'an, Shaanxi Province, 710000, China. wangxh919@fmmu.edu.cn.ORCID http://orcid.org/0000-0002-2346-4882

Funding

National Natural Science Foundation of China Grant No. 82271734National Natural Science Foundation of China Grant No. 82401962
6 · The paper itself

Abstract

backgroundControlled ovarian stimulation (COS) induces supraphysiologic levels of estrogen (E

methodsWe established mouse models for supraphysiological E

resultsCOS-induced elevated E

conclusionOur findings indicate that the low birth weight associated with COS may be attributed to elevated estrogen levels, which can adversely affect the differentiation and function of uNK cells. This disruption may lead to abnormal placental morphology and functionality. These findings may contribute to the prevention and intervention of adverse pregnancy outcomes related to COS.

Indexed as

Cell NucleusDeciduaEstrogensKiller Cells, NaturalPlacentaStromal CellsTranscription Factor RelAActive Transport, Cell NucleusAnimalsBone Morphogenetic Protein 2Coculture TechniquesCytokinesFemaleInterleukin-8MicePregnancyBone Morphogenetic Protein 2CytokinesEstrogensInterleukin-8PyrrolidinesTranscription Factor RelABMP2CXCL8DecidualizationNF-κBSupraphysiologic estrogen environmentuNK cell

Identifiers

PMID42436582
PMCPMC13644121

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.