ArticleNature and science of sleep2026
Research on Large Endothelial Cell-Derived Extracellular Vesicles in Pediatric Obstructive Sleep Apnea Syndrome.
Article in Nature and science of sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Purpose: To explore the association between clinical indicators of obstructive sleep apnea (OSA) and large endothelial cell-derived extracellular vesicles (large endothelial EVs) in children, and to explore their potential association with disease severity. Patients and Methods: A total of 81 children with OSA were enrolled, including 29 cases of mild OSA and 52 cases of moderate-to-severe OSA. Receiver operating characteristic (ROC) curves evaluated the discriminatory ability of these EVs for severity groups. The correlation between large endothelial EVs and OSA clinical results, including sleep architecture and sleep-disordered breathing events, was evaluated using Spearman correlation analysis and multiple regression analysis. Results: Levels of CD31+CD41- large endothelial EVs were significantly elevated in children with moderate-to-severe OSA compared to the mild OSA group ( Conclusion: CD31+CD41- large endothelial EVs were closely associated with OAHI and sleep efficiency. These exploratory findings suggest their potential as a biomarker of OSA severity, but prospective validation is required before clinical application.
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